Eupatilin: a natural pharmacologically active flavone compound with its wide range applications

被引:64
作者
Nageen, Bushra [1 ]
Sarfraz, Iqra [1 ]
Rasul, Azhar [1 ]
Hussain, Ghulam [2 ]
Rukhsar, Fariha [1 ]
Irshad, Somia [3 ]
Riaz, Ammara [1 ]
Selamoglu, Zeliha [4 ]
Ali, Muhammad [1 ]
机构
[1] Govt Coll Univ Faisalabad, Dept Zool, Fac Life Sci, Faisalabad 38000, Pakistan
[2] Govt Coll Univ Faisalabad, Dept Physiol, Fac Life Sci, Faisalabad 38000, Pakistan
[3] Govt Coll Univ Faisalabad, Dept Zool, Fac Life Sci, Subcampus Layyah, Layyah 31200, Pakistan
[4] Nigde Omer Halisdemir Univ, Dept Med Biol, Fac Med, TR-51240 Nigde, Turkey
关键词
Eupatilin; anti-cancer; anti-inflammatory; anti-oxidant; medicinal plants; flavone; CELL-CYCLE ARREST; GASTRIC ADENOCARCINOMA CELLS; ISCHEMIA-REPERFUSION INJURY; ARTEMISIA-PRINCEPS; SMOOTH-MUSCLE; CHEMICAL-CONSTITUENTS; FOLIAR FLAVONOIDS; AERIAL PARTS; APOPTOSIS; PLANTS;
D O I
10.1080/10286020.2018.1492565
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Eupatilin (5,7-dihydroxy-3 ',4 ',6-trimethoxyflavone) is a pharmacologically active flavone which has been isolated from a variety of medicinal plants. Eupatilin is known to possess various pharmacological properties such as anti-cancer, anti-oxidant, and anti-inflammatory. It is speculated that eupatilin could be subjected to structural optimization for the synthesis of derivative analogs to reinforce its efficacy, to minimize toxicity, and to optimize absorption profiles, which will ultimately lead towards potent drug candidates. Although, reported data acclaim multiple pharmacological activities of eupatilin but further experimentations on its molecular mechanism of action are yet mandatory to elucidate full spectrum of its pharmacological activities.
引用
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页码:1 / 16
页数:16
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