Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer

被引:29
作者
Riggs, McKayla J. [1 ]
Pandalai, Prakash K. [2 ]
Kim, Joseph [2 ]
Dietrich, Charles S. [1 ]
机构
[1] Univ Kentucky, Div Gynecol Oncol, Lexington, KY 40502 USA
[2] Univ Kentucky, Div Surg Oncol, Lexington, KY 40502 USA
关键词
HIPEC; ovarian cancer; peritoneal cancer; review; technique; LONG-TERM SURVIVAL; CYTOREDUCTIVE SURGERY; PERITONEAL CARCINOMATOSIS; RANDOMIZED-TRIAL; ONCOLOGY-GROUP; HIPEC; RECURRENT; CISPLATIN; PACLITAXEL; MULTICENTER;
D O I
10.3390/diagnostics10010043
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hyperthermic intraperitoneal chemotherapy (HIPEC) in conjunction with cytoreductive surgery (CRS) holds promise as an adjunctive treatment strategy in malignancies affecting the peritoneal surface, effectively targeting remaining microscopic residual tumor. HIPEC increases concentrations of chemotherapy directly within the peritoneal cavity compared with the intravenous route and reduces the systemic side effects associated with prolonged adjuvant intraperitoneal exposure. Furthermore, hyperthermia increases tissue penetration and is synergistic with the therapeutic chemotherapy agents used. In ovarian cancer, evidence is building for its use in both primary and recurrent scenarios. In this review, we examine the history of HIPEC, the techniques used, and the available data guiding its use in primary and recurrent ovarian cancer.
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页数:14
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