Left behind: The potential impact of CFTR modulators on racial and ethnic disparities in cystic fibrosis

被引：38

作者：

McGarry, Meghan E. ^{[1
]}

Gibb, Elizabeth R. ^{[1
]}

Oates, Gabriela R. ^{[2
]}

Schechter, Michael S. ^{[3
,4
]}

机构：

[1] Univ Calif San Francisco, Dept Pediat, Div Pulm Med, San Francisco, CA 94110 USA

[2] Univ Alabama Birmingham, Dept Pediat, Div Pulm & Sleep Med, Birmingham, AL USA

[3] Virginia Commonwealth Univ, Dept Pediat, Div Pulm & Sleep Med, Richmond, VA USA

[4] Childrens Hosp Richmond VCU, Richmond, VA USA

来源：

PAEDIATRIC RESPIRATORY REVIEWS | 2022年 / 42卷

关键词：

Cystic fibrosis; CFTR modulators; Race; Ethnicity; CIGARETTE-SMOKE; TEZACAFTOR-IVACAFTOR; SOCIOECONOMIC-STATUS; DOUBLE-BLIND; HISPANIC PATIENTS; EPITHELIAL-CELLS; PHE508DEL CFTR; PARALLEL-GROUP; RISK-FACTORS; US FOOD;

D O I：

10.1016/j.prrv.2021.12.001

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The advent of CFTR modulators, a genomic specific medication, revolutionized the treatment of CF for many patients. However, given that these therapeutics were only developed for specific CFTR mutations, not all people with CF have access to such disease-modifying drugs. Racial and ethnic minority groups are less likely to have CFTR mutations that are approved for CFTR modulators. This exclusion has the potential to widen existing health disparities.(c) 2021 Elsevier Ltd. All rights reserved.

引用

页码：35 / 42

页数：8

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