Simple synthesis of aromatic β-C-nucleosides via coupling of aryl Grignard reagents with sugar fluorides

被引：0

作者：

Yokoyama, M ^{[1
]}

Toyoshima, H ^{[1
]}

Shimizu, M ^{[1
]}

Mito, J ^{[1
]}

Togo, H ^{[1
]}

机构：

[1] Chiba Univ, Fac Sci, Dept Chem, Inage Ku, Chiba 263, Japan

来源：

SYNTHESIS-STUTTGART | 1998年 / 04期

关键词：

sugar fluorides; Grignard reagents; C-nucleosides; beta-selectivity;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The perbenzylated D-ribofuranosyl fluoride is allowed selectivity to react with Grignard reagents of aromatic heterocycles such as thiophene, pyrrole, and indole in THF to afford the corresponding beta-C-nucleosides in moderate yields. The present process can be also applied to perbenzylated D-glucopyranosyl fluoride and perperbenzylated 2-deoxy-D-ribofuranosyl fluoride as sugar donors.

引用

页码：409 / 412

页数：4

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