Antithyroid Activity of 6-Chloropurine

被引：5

作者：

Fatima, Ismat ^{[1
]}

Munawar, Munawar A. ^{[1
]}

Khan, Misbahul A. ^{[1
]}

Asmatullah ^{[2
]}

Tasneem, Afia ^{[3
]}

Khalil, Muhammad ^{[2
]}

机构：

[1] Univ Punjab Lahore, Inst Chem, Lahore, Pakistan

[2] Univ Punjab Lahore, Dept Zool, Lahore, Pakistan

[3] Mayo Hosp Lahore, Ctr Nucl Med, Lahore, Pakistan

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2010年 / 21卷 / 09期

关键词：

6-chloro-9H-purine; iodine; antithyroid activity; charge transfer complex; thyroid hormones; CHARGE-TRANSFER COMPLEXES; PURINES;

D O I：

10.1590/S0103-50532010000900015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Antithyroid activity of 6-chloropurine was determined, in vitro, by studying its complex formation with iodine spectrophotometrically. The complex exhibited a 1:1 stoichiometry. Formation constant (K-c) of the complex was found to be 7.652 x 10(3) L mol(-1), which indicated good antithyroid potential of 6-chloropurine. For further verification, changes in the thyroid hormone levels of the male rabbits were observed, in vivo, after administering the dose through intra peritoneal (i.p.) injections for 14 days and measuring free triiodothyronine (T-3) and tetraiodothyronine (T-4) levels in the blood serum using radioimmunoassay technique. The blood assays showed decrease in free T-3 and T-4 levels in the treated animals as compared to the control ones thus confirming fairly good antithyroid activity of 6-choloropurine.

引用

页码：1699 / 1703

页数：5

共 15 条

[1] Extrathyroidal actions of antithyroid thionamides [J].