Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

被引：258

作者：

Colaianni, Graziana ^{[1
]}

Mongelli, Teresa ^{[1
]}

Cuscito, Concetta ^{[1
]}

Pignataro, Paolo ^{[1
]}

Lippo, Luciana ^{[1
]}

Spiro, Giovanna ^{[2
]}

Notarnicola, Angela ^{[1
]}

Severi, Ilenia ^{[3
]}

Passeri, Giovanni ^{[4
]}

Mori, Giorgio ^{[5
]}

Brunetti, Giacomina ^{[1
]}

Moretti, Biagio ^{[1
]}

Tarantino, Umberto ^{[6
]}

Colucci, Silvia C. ^{[1
]}

Reseland, Janne E. ^{[7
]}

Vettor, Roberto ^{[2
]}

Cinti, Saverio ^{[3
]}

Grano, Maria ^{[8
]}

机构：

[1] Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, I-70124 Bari, Italy

[2] Univ Padua, Internal Med 3, Dept Med DIMED, I-35128 Padua, Italy

[3] Univ Ancona, United Hosp, Ctr Obes, Dept Expt & Clin Med, I-60020 Ancona, Italy

[4] Univ Parma, Dept Clin & Expt Med, I-43126 Parma, Italy

[5] Univ Foggia, Dept Clin & Expt Med, I-71100 Foggia, Italy

[6] Tor Vergata Univ Rome, Dept Orthoped & Traumatol, I-00133 Rome, Italy

[7] Univ Oslo, Inst Clin Dent, Dept Biomat, N-0317 Oslo, Norway

[8] Univ Bari, Dept Emergency & Organ Transplantat, I-70124 Bari, Italy

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

MINERAL DENSITY; TRABECULAR BONE; IN-VIVO; CANCELLOUS BONE; CONTRIBUTES; MYOKINE; OSTEOPOROSIS; EXPRESSION; PLASTICITY; FRACTURES;

D O I：

10.1038/s41598-017-02557-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We previously showed that Irisin, a myokine released from skeletal muscle after physical exercise, plays a central role in the control of bone mass. Here we report that treatment with recombinant Irisin prevented bone loss in hind-limb suspended mice when administered during suspension (preventive protocol) and induced recovery of bone mass when mice were injected after bone loss due to a suspension period of 4 weeks (curative protocol). MicroCT analysis of femurs showed that r-Irisin preserved both cortical and trabecular bone mineral density, and prevented a dramatic decrease of the trabecular bone volume fraction. Moreover, r-Irisin protected against muscle mass decline in the hind-limb suspended mice, and maintained the fiber cross-sectional area. Notably, the decrease of myosin type II expression in unloaded mice was completely prevented by r-Irisin administration. Our data reveal for the first time that Irisin retrieves disuse-induced bone loss and muscle atrophy. These findings may lead to development of an Irisin-based therapy for elderly immobile osteoporotic and physically disable patients, and might represent a countermeasure for astronauts subjected to microgravity-induced bone and muscle losses.

引用

页数：16

共 49 条

[1] Assessment of 2D and 3D fractal dimension measurements of trabecular bone from high-spatial resolution magnetic resonance images at 3 T [J].