Immunomodulation by Intravenous Immunoglobulin: Role of Regulatory T Cells

被引：60

作者：

Maddur, Mohan S. ^{[1
,2
,3
]}

Othy, Shivashankar ^{[1
,2
,3
]}

Hegde, Pushpa ^{[1
,2
,3
]}

Vani, Janakiraman ^{[1
,2
,3
]}

Lacroix-Desmazes, Sebastien ^{[1
,2
,3
]}

Bayry, Jagadeesh ^{[1
,2
,3
]}

Kaveri, Srini V. ^{[1
,2
,3
]}

机构：

[1] Univ Paris 06, Ctr Rech Cordeliers, Equipe Immunopathol & Therapeut Immunointervent 1, UMR S 872, F-75006 Paris, France

[2] Univ Paris 05, UMR S 872, F-75006 Paris, France

[3] INSERM, Unite 872, F-75006 Paris, France

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2010年 / 30卷

关键词：

IVIG; intravenous immunoglobulin; regulatory T cells; autoimmune diseases; inflammation; immunomodulation; MONOCLONAL-ANTIBODY; MECHANISMS; THERAPY; CTLA-4; AUTOIMMUNITY; SUPPRESSION; TREGITOPES; TOLERANCE; DISEASES;

D O I：

10.1007/s10875-010-9394-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An altered immune homeostasis as a result of deficiency or defective function of CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) is common in several autoimmune diseases. Hence, therapeutic strategies to render Tregs functionally competent are being investigated. Intravenous immunoglobulin (IVIG) is being increasingly used for the treatment of a wide range of autoimmune and inflammatory diseases. Recent studies have demonstrated that IVIG induces the expansion of Tregs and enhances their suppressive functions. These effects of IVIG on Tregs correlate with the beneficial effects of IVIG in patients with autoimmune diseases. Thus, modulation of Tregs by IVIG represents a novel mode of action that explains the therapeutic effects of IVIG in T cell-mediated autoimmune diseases. However, the molecular mechanisms involved in IVIG-mediated modulation of Tregs are unclear and need further investigation.

引用

页码：S4 / S8

页数：5

共 24 条

[11] CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance [J].