Nanotechnology-Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID-19 Vaccines

被引：51

作者：

Rinoldi, Chiara ^{[1
]}

Zargarian, Seyed Shahrooz ^{[1
]}

Nakielski, Pawel ^{[1
]}

Li, Xiaoran ^{[2
]}

Liguori, Anna ^{[3
,4
]}

Petronella, Francesca ^{[5
]}

Presutti, Dario ^{[6
]}

Wang, Qiusheng ^{[2
]}

Costantini, Marco ^{[6
]}

de Sio, Luciano ^{[7
,8
]}

Gualandi, Chiara ^{[3
,4
,9
]}

Ding, Bin ^{[2
]}

Pierini, Filippo ^{[1
]}

机构：

[1] Polish Acad Sci, Dept Biosyst & Soft Matter, Inst Fundamental Technol Res, Ul Pawinskiego 5B, PL-02106 Warsaw, Poland

[2] Donghua Univ, Innovat Ctr Text Sci & Technol, West Yanan Rd 1882, Shanghai 200051, Peoples R China

[3] Univ Bologna, Dept Chem Giacomo Ciamician, Via Selmi 2, I-40126 Bologna, Italy

[4] Univ Bologna, INSTM UdR Bologna, Via Selmi 2, I-40126 Bologna, Italy

[5] Natl Res Council Italy, Inst Crystallog CNR IC, Via Salaria Km 29-300, I-00015 Rome, Italy

[6] Polish Acad Sci, Inst Phys Chem, Ul M Kasprzaka 44-52, PL-01224 Warsaw, Poland

[7] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, Res Ctr Biophoton, Corso Repubbl 79, I-04100 Latina, Italy

[8] Inst NANOTEC, CNR Lab Licryl, I-87036 Arcavacata Di Rende, Italy

[9] Univ Bologna, CIRI MAM, Interdept Ctr Ind Res Adv Applicat Mech Engn & Ma, Viale Risorgimento 2, I-40136 Bologna, Italy

来源：

SMALL METHODS | 2021年 / 5卷 / 09期

关键词：

COVID-19; drug delivery; nanostructured biomaterials; personalized therapy; ribonucleic acids; SMALL INTERFERING RNA; MESOPOROUS SILICA NANOPARTICLES; MODIFIED MESSENGER-RNA; SIRNA DELIVERY; ALPHA-SYNUCLEIN; TARGETED DELIVERY; GENE-EXPRESSION; GRAPHENE OXIDE; LUNG-CANCER; CHITOSAN NANOPARTICLES;

D O I：

10.1002/smtd.202100402

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In recent years, the main quest of science has been the pioneering of the groundbreaking biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids (RNAs) are outstanding bioactive macromolecules identified as pivotal actors in regulating a wide range of biochemical pathways. The ability to intimately control the cell fate and tissue activities makes RNA-based drugs the most fascinating family of bioactive agents. However, achieving a widespread application of RNA therapeutics in humans is still a challenging feat, due to both the instability of naked RNA and the presence of biological barriers aimed at hindering the entrance of RNA into cells. Recently, material scientists' enormous efforts have led to the development of various classes of nanostructured carriers customized to overcome these limitations. This work systematically reviews the current advances in developing the next generation of drugs based on nanotechnology-assisted RNA delivery. The features of the most used RNA molecules are presented, together with the development strategies and properties of nanostructured vehicles. Also provided is an in-depth overview of various therapeutic applications of the presented systems, including coronavirus disease vaccines and the newest trends in the field. Lastly, emerging challenges and future perspectives for nanotechnology-mediated RNA therapies are discussed.

引用

页数：49

共 380 条

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