Cortical KCNQ2/3 channels; insights from knockout mice

被引:2
作者
Sohy, Heun [1 ]
Nidayy, Zachary [1 ]
Tzingounis, Anastasios V. [1 ]
机构
[1] Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT 06269 USA
关键词
Epilepsy; KCNQ2; KCNQ3; M-current; medium afterhyperpolarization; epilepsy; ACTION-POTENTIAL INITIATION; NEURONAL EXCITABILITY; SEIZURES; AXONS;
D O I
10.4161/19336950.2014.948755
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:389 / 390
页数:2
相关论文
共 50 条
  • [21] Three mechanisms underlie KCNQ2/3 heteromeric potassium M-channel potentiation
    Etxeberria, A
    Santana-Castro, I
    Regalado, MP
    Aivar, P
    Villarroel, A
    JOURNAL OF NEUROSCIENCE, 2004, 24 (41) : 9146 - 9152
  • [22] Made for "anchorin": Kv7.2/7.3 (KCNQ2/KCNQ3) channels and the modulation of neuronal excitability in vertebrate axons
    Cooper, Edward C.
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2011, 22 (02) : 185 - 192
  • [23] Antibodies and a cysteine-modifying reagent show correspondence of M current in neurons to KCNQ2 and KCNQ3 K+ channels
    Roche, JP
    Westenbroek, R
    Sorom, AJ
    Hille, B
    Mackie, K
    Shapiro, MS
    BRITISH JOURNAL OF PHARMACOLOGY, 2002, 137 (08) : 1173 - 1186
  • [24] A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel
    Bai, Fang
    Pi, Xiaoping
    Li, Ping
    Zhou, Pingzheng
    Yang, Huaiyu
    Wang, Xicheng
    Li, Min
    Gao, Zhaobing
    Jiang, Hualiang
    FRONTIERS IN PHARMACOLOGY, 2018, 9
  • [25] Kcnq2/Kv7.2 controls the threshold and bi-hemispheric symmetry of cortical spreading depolarization
    Aiba, Isamu
    Noebels, Jeffrey L.
    BRAIN, 2021, 144 : 2863 - 2878
  • [26] Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel
    Zhang, Xu-Feng
    Han, Ping
    Neelands, Torben R.
    McGaraughty, Steve
    Honore, Prisca
    Surowy, Carol S.
    Zhang, Di
    JOURNAL OF GENERAL PHYSIOLOGY, 2011, 138 (03) : 341 - 352
  • [27] Ezogabine (KCNQ2/3 channel opener) prevents delayed activation of meningeal nociceptors if given before but not after the occurrence of cortical spreading depression
    Zhang, XiChun
    Jakubowski, Moshe
    Buettner, Catherine
    Kainz, Vanessa
    Gold, Michael
    Burstein, Rami
    EPILEPSY & BEHAVIOR, 2013, 28 (02) : 243 - 248
  • [28] Developmental changes in KCNQ2 and KCNQ3 expression in human brain: Possible contribution to the age-dependent etiology of benign familial neonatal convulsions
    Kanaumi, Takeshi
    Takashima, Sachio
    Iwasaki, Hiroshi
    Itoh, Masayuki
    Mitsudome, Akihisa
    Hirose, Shinichi
    BRAIN & DEVELOPMENT, 2008, 30 (05) : 362 - 369
  • [29] Loss of KCNQ2 or KCNQ3 leads to multifocal time-varying activity in the neonatal forebrain ex vivo
    Hou, Bowen
    Varghese, Nissi
    Soh, Heun
    Santaniello, Sabato
    Tzingounist, Anastasios V.
    ENEURO, 2021, 8 (03)
  • [30] Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1
    Schuetz, Friderike
    Kumar, Sharad
    Poronnik, Philip
    Adams, David J.
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2008, 295 (01): : C73 - C80