The SYK tyrosine kinase: a crucial player in diverse biological functions

被引：1057

作者：

Mocsai, Attila ^{[1
]}

Ruland, Juergen ^{[2
,3
]}

Tybulewicz, Victor L. J. ^{[4
]}

机构：

[1] Semmelweis Univ, Sch Med, Dept Physiol, H-1094 Budapest, Hungary

[2] Tech Univ Munich, Klinikum Rechts Isar, Med Klin 3, Inst Mol Immunol, D-81675 Munich, Germany

[3] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Lab Signalling Immune Syst, D-85764 Neuherberg, Germany

[4] MRC Natl Inst Med Res, Div Immune Cell Biol, London NW7 1AA, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 06期

基金：

欧洲研究理事会; 英国惠康基金; 英国医学研究理事会;

关键词：

C-TYPE LECTIN; B-CELL DEVELOPMENT; NF-KAPPA-B; RECEPTOR GAMMA-CHAIN; FC-EPSILON-RI; PATTERN-RECOGNITION RECEPTOR; SEVERE COMBINED IMMUNODEFICIENCY; PHOSPHOTYROSINE-BINDING DOMAIN; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA;

D O I：

10.1038/nri2765

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome. Studies using Drosophila melanogaster suggest that there is an evolutionarily ancient origin of SYK-mediated signalling. Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies. This Review summarizes our current understanding of the diverse functions of SYK and how this is being translated for therapeutic purposes.

引用

页码：387 / 402

页数：16

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