lncRNA/MicroRNA Interactions in the Vasculature

被引：246

作者：

Ballantyne, M. D. ^{[1
,2
]}

McDonald, R. A. ^{[1
]}

Baker, A. H. ^{[1
]}

机构：

[1] Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland

[2] British Heart Fdn Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2016年 / 99卷 / 05期

关键词：

LONG NONCODING RNAS; INTERLEUKIN-1 RECEPTOR ANTAGONIST; MUSCLE-CELL PROLIFERATION; NEOINTIMA FORMATION; EMERGING ROLES; BALLOON INJURY; ANGIOTENSIN-II; WALL CELLS; MICRORNA; GROWTH;

D O I：

10.1002/cpt.355

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

MicroRNA (miRNA) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation, and migration. Despite great understanding of miRNA expression and function, knowledge of long noncoding RNA (lncRNA) molecular mechanisms still remains limited. The influence of miRNA on lncRNA function, and the converse, is now beginning to emerge. lncRNA may regulate miRNA function by acting as endogenous sponges to regulate gene expression and miRNA have been shown to bind and regulate lncRNA stability. A detailed understanding of the molecular and cellular effects of lncRNA-miRNA-mediated interactions in vascular pathophysiology could pave the way for new diagnostic markers and therapeutic approaches, but first there is a requirement for a more detailed understanding of the impact of such regulatory networks.

引用

页码：494 / 501

页数：8

共 68 条

[1] Acute Loss of miR-221 and miR-222 in the Atherosclerotic Plaque Shoulder Accompanies Plaque Rupture [J].

Bazan, Hernan A. ;

Hatfield, Samuel A. ;

O'Malley, Chasity B. ;

Brooks, Ashton J. ;

Lightell, Daniel, Jr. ;

Woods, T. Cooper .

STROKE, 2015, 46 (11) :3285-3287

[2] Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension [J].

Bertero, Thomas ;

Lu, Yu ;

Annis, Sofia ;

Hale, Andrew ;

Bhat, Balkrishen ;

Saggar, Rajan ;

Saggar, Rajeev ;

Wallace, W. Dean ;

Ross, David J. ;

Vargas, Sara O. ;

Graham, Brian B. ;

Kumar, Rahul ;

Black, Stephen M. ;

Fratz, Sohrab ;

Fineman, Jeffrey R. ;

West, James D. ;

Haley, Kathleen J. ;

Waxman, Aaron B. ;

Chau, B. Nelson ;

Cottrill, Katherine A. ;

Chan, Stephen Y. .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (08) :3514-3528

[3] Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway [J].

Brown, KW ;

Villar, AJ ;

Bickmore, W ;

ClaytonSmith, J ;

Catchpoole, D ;

Maher, ER ;

Reik, W .

HUMAN MOLECULAR GENETICS, 1996, 5 (12) :2027-2032

[4]

Buttery LDK, 1996, J PATHOL, V179, P197, DOI 10.1002/(SICI)1096-9896(199606)179:2<197::AID-PATH587>3.0.CO

[5]

2-D

[6] Origins and Mechanisms of miRNAs and siRNAs [J].

Carthew, Richard W. ;

Sontheimer, Erik J. .

CELL, 2009, 136 (04) :642-655

[7] Interleukin-1β and signaling of interleukin-1 in vascular wail and circulating cells modulates the extent of neointima formation in mice [J].

Chamberlain, J ;

Evans, D ;

King, A ;

Dewberry, R ;

Dower, S ;

Crossman, D ;

Francis, S .

AMERICAN JOURNAL OF PATHOLOGY, 2006, 168 (04) :1396-1403

[8] A Unique MicroRNA Signature Associated With Plaque Instability in Humans [J].

Cipollone, Francesco ;

Felicioni, Lara ;

Sarzani, Riccardo ;

Ucchino, Sante ;

Spigonardo, Francesco ;

Mandolini, Claudia ;

Malatesta, Sara ;

Bucci, Marco ;

Mammarella, Chiara ;

Santovito, Donato ;

de Lutiis, Federica ;

Marchetti, Antonio ;

Mezzetti, Andrea ;

Buttitta, Fiamma .

STROKE, 2011, 42 (09) :2556-2563

[9]

Clark MB, 2015, NAT METHODS, V12, P339, DOI [10.1038/NMETH.3321, 10.1038/nmeth.3321]

[10] Finishing the euchromatic sequence of the human genome [J].

Collins, FS ;

Lander, ES ;

Rogers, J ;

Waterston, RH .

NATURE, 2004, 431 (7011) :931-945

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