A new approach to the synthesis of functionalized pyrido[2,3-b]lindoles by way of a palladium-catalyzed ring closing reaction between the N-1 and C-9a positions

被引：46

作者：

Abouabdellah, A ^{[1
]}

Dodd, RH ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(98)00065-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enolate of 4-N-(tert-butyloxycarbonyl)aminobutyro-gamma-lactone 9 reacted with 2-bromo-1-methylindole-3-carboxaldehyde in the presence of stannic chloride to give the product of aldol condensation 16 Deprotection and dehydration of the latter with trifluoroacetic acid and dimethyl sulfide followed by Pd-2(dba)(3)-catalyzed ring closing of the product afforded the alpha-carboline 6 in good overall yield. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2119 / 2122

页数：4

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