Autism and phenylketonuria

被引:80
作者
Baieli, S
Pavone, L
Meli, C
Fiumara, A
Coleman, M
机构
[1] Univ Catania, Dept Paediat, Div Paediat Neurol, I-95123 Catania, Italy
[2] Univ Catania, Dept Paediat, Reg Ctr Inborn Errors Metab, I-95124 Catania, Italy
[3] Georgetown Univ, Sch Med, Dept Paediat, Washington, DC USA
关键词
phenylketonuria; autism association;
D O I
10.1023/A:1022999712639
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Phenylketonuria (PKU) has been also reported in children with infantile autism (IA); however, the frequency of this association is variably reported. Patients with various forms of hyperphenylalaninemia (HPA) were evaluated applying two methods: the Autism Diagnostic Interview-Revised (ADI-R) and the Childhood Autism Rating Scale (CARS). A total of 243 patients were investigated, 97 with classical PKU, 62 identified by neonatal screening, and 35 late diagnosed. None out of 62 patients with classic PKU diagnosed early met criteria for autism. In the group of 35 patients diagnosed late, two boys (5.71%) ages 16 and 13 years fulfilled the diagnostic criteria for autism. The present study confirms that classical PKU is one of the causes of autism, but the prevalence seems to be very low.
引用
收藏
页码:201 / 204
页数:4
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