Fibrin stabilization (factor XIII), fibrin structure and thrombosis

被引：35
作者：
Bereczky, Z
Katona, É
Muszbek, L
机构：
[1] Univ Debrecen, Med & Hlth Sci Ctr, Clin Res Ctr, Hungarian Acad Sci, H-4012 Debrecen, Hungary
[2] Univ Debrecen, Med & Hlth Sci Ctr, Thrombosis Res Grp, Hungarian Acad Sci, H-4012 Debrecen, Hungary
来源：
PATHOPHYSIOLOGY OF HAEMOSTASIS AND THROMBOSIS | 2003年 / 33卷 / 5-6期
关键词：
factor XIII; factor XIII-A Val34Leu polymorphism; fibrinolysis; thrombosis;
D O I：
10.1159/000083841
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Factor XIII (FXIII) is a zymogen that is converted into an active transglutaminase (FXIIIa) by the concerted action of thrombin and Ca2+. Its main task is to crosslink alpha-, and gamma-chains of fibrin and alpha2-plasmin inhibitor to fibrin. By this way FXlIIa strengthens fibrin and protects it from the prompt elimination by fibrinolytic system. The changes of FXIII level in thrombotic diseases are hardly explored and there are contradictory results concerning the protective effect of Val34Leu polymorphism against arterial or venous thrombosis. The results suggest that the thrombo-protective effect of Leu34 allele prevails only in certain genetic and/or environmental constellations. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码：430 / 437
页数：8
相关论文
共 108 条
[21]   Venous and intracoronary factor XIII A-subunit antigen and activity levels are not associated with extent of coronary artery disease [J].
Chatterjee, T ;
Schroeder, V ;
Windecker, S ;
Meier, B ;
Kohler, HP .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2003, 1 (04) :861-863
[22]  
Corral J, 2000, HAEMATOLOGICA, V85, P293
[23]  
DVORAK HF, 1984, CANCER RES, V44, P3348
[24]   The association between the Val34Leu polymorphism in the factor XIII gene and brain infarction [J].
Elbaz, A ;
Poirier, O ;
Canaple, S ;
Chédru, F ;
Cambien, F ;
Amarenco, P .
BLOOD, 2000, 95 (02) :586-591
[25]   Is the factor XIII 34Val/Leu polymorphism a protective factor for cerebrovascular disease? [J].
Endler, G ;
Funk, M ;
Haering, D ;
Lalouschek, W ;
Lang, W ;
Mirafzal, M ;
Wagner, O ;
Mannhalter, C .
BRITISH JOURNAL OF HAEMATOLOGY, 2003, 120 (02) :310-314
[26]  
Folk J E, 1977, Adv Protein Chem, V31, P1, DOI 10.1016/S0065-3233(08)60217-X
[27]  
Francis CW, 2002, ARCH PATHOL LAB MED, V126, P1391
[28]  
FRANCIS CW, 1988, BLOOD, V71, P1361
[29]  
Franco RF, 2000, HAEMATOLOGICA, V85, P67
[30]  
Franco RF, 1999, THROMB HAEMOSTASIS, V81, P676
12345678910