C/EBPA gene mutation and C/EBPA promoter hypermethylation in acute myeloid leukemia with normal cytogenetics
被引:17
作者:
Lu, Ying
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City Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA
Ningbo NO 1 Hosp, Dept Hematol, Ningbo, Zhejiang, Peoples R ChinaCity Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA
Lu, Ying
[1
,2
]
Chen, Wengang
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机构:
City Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USACity Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA
Chen, Wengang
[1
]
Chen, Wei
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机构:
City Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA
Zhejiang Univ, Coll Med, Sir Run Run Hosp, Dept Oncol, Hangzhou 310003, Zhejiang, Peoples R ChinaCity Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA
Chen, Wei
[1
,3
]
Stein, Anthony
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机构:City Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA
Stein, Anthony
Weiss, Lawrence M.
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机构:
City Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USACity Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA
Weiss, Lawrence M.
[1
]
Huang, Qin
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机构:
City Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USACity Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA
Huang, Qin
[1
]
机构:
[1] City Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA
[2] Ningbo NO 1 Hosp, Dept Hematol, Ningbo, Zhejiang, Peoples R China
[3] Zhejiang Univ, Coll Med, Sir Run Run Hosp, Dept Oncol, Hangzhou 310003, Zhejiang, Peoples R China
In the current study, we investigated C/EBPA gene mutations and promoter hypermethylation in a series of 53 patients with CN-AML. In addition, we also analyzed two other frequent mutations (FLT3/ITD and NPM1) in these patients and correlated them with C/EBPA gene alterations. 13/53 patients were FLT3/ITD+/NPM1-, 11/53 patients were FLT3/ITD+/NPM1+, 9/53 patients were FLT3/ITD-/NPM1+, and 20/53 patients were FLT3/ITD-/NPM1-. Four of 53 cases displayed C/EBPA mutations, whereas 49 cases had only C/EBPA wildtype alleles. Of the four positive cases, three patients had N-terminal mutations only, whereas one patient had mutations in both the N- and C-terminal region. Two of the four positive cases also harbored both FLT3/ITD and NPM1 mutation simultaneously, whereas the other two patients had neither FLT3/ITD nor NPM1 mutations. Furthermore, 7/53 cases displayed C/EBPA promoter hypermethylation. Interestingly, they were all in CN-AML cases without FLT3/ITD or NPM1 mutations. None of the seven patients with C/EBPA promoter hypermethylation showed C/EBPA mutation. In conclusion, C/EBPA mutation and promoter hypermethylation can be detected at a relatively low frequency in de novo CN-AML patients, suggesting they may contribute to leukemogenesis. C/EBPA mutation appears to be seen in "high-risk" AML (FLT3/ITD+/NPM1+; FLT3/ITD+/NPM1- or FLT3/ITD-/NPM1-), while C/EBPA hypermethylation appears to be more common in AML with FLT3/ITD- INPM1- and is not associated with C/EBPA mutation. Am. J. Hematol. 85:426-430, 2010. (C) 2010 Wiley-Liss, Inc.
机构:
Univ Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R China
Chim, CS
Wong, ASY
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机构:
Univ Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R China
Wong, ASY
Kwong, YL
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h-index: 0
机构:
Univ Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R China
机构:
Weill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Figueroa, Maria E.
Wouters, Bas J.
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h-index: 0
机构:
Erasmus Univ, Dept Hematol, Med Ctr, Rotterdam, NetherlandsWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Wouters, Bas J.
Skrabanek, Lucy
论文数: 0引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll, Dept Physiol & Biophys, New York, NY 10021 USA
Weill Cornell Med Coll, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10021 USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Skrabanek, Lucy
Glass, Jacob
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Mol Genet, New York, NY USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Glass, Jacob
Li, Yushan
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h-index: 0
机构:
Weill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Li, Yushan
Erpelinck-Verschueren, Claudia A. J.
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h-index: 0
机构:
Erasmus Univ, Dept Hematol, Med Ctr, Rotterdam, NetherlandsWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Erpelinck-Verschueren, Claudia A. J.
Langerak, Anton W.
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h-index: 0
机构:
Erasmus Univ, Dept Immunol, Med Ctr, NL-3000 DR Rotterdam, NetherlandsWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Langerak, Anton W.
Lowenberg, Bob
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h-index: 0
机构:
Erasmus Univ, Dept Hematol, Med Ctr, Rotterdam, NetherlandsWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Lowenberg, Bob
Fazzari, Melissa
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Fazzari, Melissa
Greally, John M.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Mol Genet, New York, NY USA
Albert Einstein Coll Med, Dept Med, New York, NY USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Greally, John M.
Valk, Peter J. M.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus Univ, Dept Hematol, Med Ctr, Rotterdam, NetherlandsWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Valk, Peter J. M.
Melnick, Ari
论文数: 0引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Melnick, Ari
Delwel, Ruud
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h-index: 0
机构:
Erasmus Univ, Dept Hematol, Med Ctr, Rotterdam, NetherlandsWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
机构:
Univ Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R China
Chim, CS
Wong, ASY
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R China
Wong, ASY
Kwong, YL
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R China
机构:
Weill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Figueroa, Maria E.
Wouters, Bas J.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus Univ, Dept Hematol, Med Ctr, Rotterdam, NetherlandsWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Wouters, Bas J.
Skrabanek, Lucy
论文数: 0引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll, Dept Physiol & Biophys, New York, NY 10021 USA
Weill Cornell Med Coll, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10021 USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Skrabanek, Lucy
Glass, Jacob
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Mol Genet, New York, NY USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Glass, Jacob
Li, Yushan
论文数: 0引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Li, Yushan
Erpelinck-Verschueren, Claudia A. J.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus Univ, Dept Hematol, Med Ctr, Rotterdam, NetherlandsWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Erpelinck-Verschueren, Claudia A. J.
Langerak, Anton W.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus Univ, Dept Immunol, Med Ctr, NL-3000 DR Rotterdam, NetherlandsWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Langerak, Anton W.
Lowenberg, Bob
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus Univ, Dept Hematol, Med Ctr, Rotterdam, NetherlandsWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Lowenberg, Bob
Fazzari, Melissa
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Fazzari, Melissa
Greally, John M.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Mol Genet, New York, NY USA
Albert Einstein Coll Med, Dept Med, New York, NY USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Greally, John M.
Valk, Peter J. M.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus Univ, Dept Hematol, Med Ctr, Rotterdam, NetherlandsWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Valk, Peter J. M.
Melnick, Ari
论文数: 0引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USAWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA
Melnick, Ari
Delwel, Ruud
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus Univ, Dept Hematol, Med Ctr, Rotterdam, NetherlandsWeill Cornell Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA