Green self-assembly of zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites with high cytotoxicity and immune organs targeting

被引：8

作者：

Wang, Hua-Jie ^{[1
,2
]}

Cao, Ying ^{[1
]}

Wang, Cai-Feng ^{[1
]}

Cui, Shi-Zhong ^{[1
]}

Mi, Li-Wei ^{[1
]}

Miyazawa, Teruo ^{[1
,2
]}

机构：

[1] Zhongyuan Univ Technol, Ctr Adv Mat Res, 1 Huaihe Rd, Zhengzhou 451191, Peoples R China

[2] Tohoku Univ, New Ind Creat Hatchery Ctr NICHe, Sendai, Miyagi 9800845, Japan

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

美国国家科学基金会;

关键词：

ZINC-OXIDE PARTICLES; OXIDATIVE STRESS; CONTROLLED PRECIPITATION; MECHANICAL-PROPERTIES; QUANTUM DOTS; CORN PROTEIN; NANOPARTICLES; TOXICITY; ZNO; BIOCOMPATIBILITY;

D O I：

10.1038/srep24387

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inorganic nanomedicines in the fight against cancer have progressed rapidly during recent years, with the synergistic advantages of multifunctional nanosystems compared to single component. Herein, a drug-combination opinion was introduced into "nanomedicine" based on the understanding of Trojan horse-anti-tumor mechanism of inorganic nano-medicines. Moreover, we reported the green and facile synthesis route of mono-dispersed and rod-like zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites. We found that the nanocomposites exhibited high-efficiency killing ability to tumor cells through lipid peroxidation mediated-membrane disintegration route. The safety studies in BALB/c mice didn't detect injection anaphylaxis, hemolysis and cytotoxicity. More interestingly, the nanocomposites could specially accumulate in liver and kidney, which will be helpful for targeting cure to these regional cancers.

引用

页数：8