Enantioselective α-Amination of 1,3-Dicarbonyl Compounds Using Squaramide Derivatives as Hydrogen Bonding Catalysts

被引：226
作者：
Konishi, Hideyuki [1 ]
Lam, Tin Yiu [1 ]
Malerich, Jeremiah P. [1 ]
Rawal, Viresh H. [1 ]
机构：
[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 09期
基金：
美国国家卫生研究院;
关键词：
BETA-KETO-ESTERS; DIELS-ALDER REACTIONS; AMINO-ACIDS; ELECTROPHILIC AMINATION; ASYMMETRIC-SYNTHESIS; BIFUNCTIONAL ORGANOCATALYSTS; CARBONYL-COMPOUNDS; STEREOSELECTIVE-SYNTHESIS; MICHAEL ADDITION; RECENT PROGRESS;
D O I：
10.1021/ol1005104
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Catalytic enantioselective alpha-hydrazination of 1,3-dicarbonyl compounds with azodicarboxylates was investigated in the presence of our newly developed hydrogen bonding catalyst, squaramide 3j. High yields and high enantioselectivities were achieved with low catalyst loading under mild conditions.
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收藏
页码：2028 / 2031
页数：4
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