A dramatic effect of oxygen on protection of human cells against γ-radiation by lycopene

被引：26

作者：

Boehm, Fritz ^{[1
]}

Edge, Ruth ^{[2
]}

Truscott, Terence George ^{[3
]}

Witt, Christian ^{[4
]}

机构：

[1] IHZ, Photobiol Res, Berlin, Germany

[2] Univ Manchester, Dalton Cumbrian Facil, Westlakes Sci & Technol Pk, Manchester, Cumbria, England

[3] Keele Univ, Sch Phys & Geog Sci, Chem Sect, Keele ST5 5BG, Staffs, England

[4] Univ Med, Charite Hosp, Dept Pneumonol, Berlin, Germany

来源：

FEBS LETTERS | 2016年 / 590卷 / 08期

关键词：

cell protection; dietary lycopene; gamma radiation; lymphoid cells; oxygen effect; CAROTENOID RADICAL CATIONS; LASER FLASH-PHOTOLYSIS; BETA-CAROTENE; LIPOPROTEIN OXIDATION; AQUEOUS-SOLUTIONS; SINGLET OXYGEN; ANTIOXIDANT; RADIOLYSIS; REACTIVITY; CHEMISTRY;

D O I：

10.1002/1873-3468.12134

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reducing radiation damage is important and dietary antioxidants that can protect cells from such damage are of value. Dietary lycopene, a carotenoid found in tomatoes, protects human lymphoid cell membranes from damage by gamma-radiation. We report that such protective effects are remarkably reduced as the oxygen concentration increases - near zero at 100% oxygen from fivefold protection at 20% oxygen and, dramatically, from 50-fold protection at 0% oxygen. Such huge differences imply that under higher oxygen concentrations lycopene could lead to improved cancer therapy using gamma-radiation. The cells are not efficiently protected from the superoxide radical by lycopene. Noncellular studies suggest molecular mechanisms for the oxygen effect.

引用

页码：1086 / 1093

页数：8

共 35 条

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