Molecular features of thyroid oncocytic tumors

被引：35
作者：
Gasparre, Giuseppe [2 ]
Bonora, Elena
Tallini, Giovanni [3 ]
Romeo, Giovanni [1 ]
机构：
[1] Univ Bologna, UO Genet Med, Dip Sci Ginecol Ostetr & Pediat, Policlin Univ S Orsola Malpighi, I-40138 Bologna, Italy
[2] Univ Bari, Dip Biochim & Biol Mol E Quagliariello, I-70121 Bari, Italy
[3] Univ Bologna, Dip Anat Patol, Osped Bellaria, I-40138 Bologna, Italy
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2010年 / 321卷 / 01期
关键词：
Oncocytic tumors; mtDNA mutations; Follicular tumors; Papillary tumors; COMPARATIVE GENOMIC HYBRIDIZATION; MITOCHONDRIAL-DNA MUTATIONS; HURTHLE CELL TUMORS; CYTOCHROME-C-OXIDASE; COMPLEX-I; PAPILLARY CARCINOMA; RESPIRATORY-CHAIN; COMMON DELETION; BRAF MUTATIONS; CHROMOSOMAL-ABERRATIONS;
D O I：
10.1016/j.mce.2010.02.022
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Thyroid oncocytic neoplasms are tumors composed of cells characterized by an aberrant increase of mitochondrial mass. They represent a subset of thyroid tumors whose classification and clinical features has been a matter of controversy for clinicians and pathologists alike. The prevalence of oncocytic tumors in the thyroid gland, the relevance of the issues debated, and the obvious cellular derangement of oncocytic cells, namely a complete deregulation of the mitochondrial mass and metabolism, have spurred many investigators to study the molecular mechanism underlying the genesis of this peculiar cancer phenotype. Their findings, which are unraveling the tumor pathobiology, are the subject of the present review. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：67 / 76
页数：10
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