Rhodium-catalyzed enantioselective hydrogenation using chiral monophosphonite ligands

被引：137

作者：

Reetz, MT ^{[1
]}

Sell, T ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 33期

关键词：

enantioselection; reduction; rhodium and compounds; phosphorus compounds; amino acids and derivatives;

D O I：

10.1016/S0040-4039(00)01099-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Surprisingly high enantioselectivities in the Rh-catalyzed hydrogenation of itaconic acid dimethyl eater and methyl-2-acetamido acrylate are observed upon using chiral monophosphonite ligands derived from binaphthol (ee up to 94%). Although appropriate chelating diphosphonites are more effective, the easy modular synthesis of the chiral monophosphonites may allow for the optimization of a given asymmetric hydrogenation reaction. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：6333 / 6336

页数：4

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