Solvent-free one-pot synthesis of polysubstituted tetrahydropyrimidines and their antioxidant and antimicrobial properties

被引：4

作者：

Myadaraboina, Shailaja ^{[1
]}

Alla, Manjula ^{[1
]}

Parlapalli, Arunadevi ^{[1
]}

Manda, Sarangapani ^{[2
]}

机构：

[1] CSIR, Indian Inst Chem Technol, Crop Protect Chem Div, Hyderabad 500607, Andhra Pradesh, India

[2] Kakatiya Univ, Dept Med Chem, UCPSc, Warangal, Andhra Pradesh, India

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2016年 / 42卷 / 02期

关键词：

Multicomponent reaction (MCR); Acetylene dicarboxylates; Amines; Bromo(dimethylsulfonium) bromide (BDMS); Polysubstituted tetrahydropyrimidines; Antioxidant; Antimicrobial; BETA-AMINO KETONES; EFFICIENT SYNTHESIS; CATALYST;

D O I：

10.1007/s11164-015-2063-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A versatile and highly efficient one-pot multicomponent approach for the synthesis of novel multisubstituted tetrahydropyrimidine (dimethyl/diethyl-1,3-disubstituted-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate) derivatives catalyzed by Bromo(dimethylsulfonium) bromide under solvent-free conditions has been developed. The protocol is eco-friendly, operationally simple, and proceeds in short reaction time, providing high-yield, high-purity (90-95 %) stable target compounds without any side products. Further, the scope of this protocol extended to aliphatic substrates, thus establishing the versatility of the catalyst. The lead compounds were screened for antioxidant and antimicrobial activities. Among them, compounds 4a, 4d, 4e, 4j exhibited excellent antibacterial activity when compared with the standard gentamycin. Compounds 4e and 4k exhibited excellent antifungal activity in comparison with the standard itraconazole. The results of this study revealed that all synthesized compounds were significantly scavenged DPPH free radicals in a concentration-dependent manner. The IC50 values of the compounds is between 13.28 and 23.16 A mu M when compared with the standard ascorbic acid. Compound 4f was found to be a good antioxidant.

引用

页码：923 / 937

页数：15

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