Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome-A Review

被引：48

作者：

Varbiro, Szabolcs ^{[1
,2
]}

Takacs, Istvan ^{[3
]}

Tuu, Laszlo ^{[4
]}

Nas, Katalin ^{[4
]}

Sziva, Reka Eszter ^{[1
,2
,5
]}

Hetthessy, Judit Reka ^{[2
]}

Torok, Marianna ^{[1
,2
]}

机构：

[1] Semmelweis Univ, Dept Obstet & Gynecol, Ulloi St 78-A, H-1082 Budapest, Hungary

[2] Semmelweis Univ, Doctoral Sch, Workgrp Res Management, Ulloi St 22, H-1085 Budapest, Hungary

[3] Semmelweis Univ, Dept Internal Med & Oncol, Sandor Koranyi St 2-A, H-1098 Budapest, Hungary

[4] Endocrinol Ctr, EndoCare Inst, Bokor St 17-21, H-1037 Budapest, Hungary

[5] Semmelweis Univ, Dept Physiol, Tuzolto St 37-47, H-1094 Budapest, Hungary

来源：

NUTRIENTS | 2022年 / 14卷 / 08期

关键词：

polycystic ovary syndrome; PCOS; vitamin D; vitamin D deficiency; vitamin D supplementation; female fertility; male fertility; in vitro fertilization; pregnancy; reproductive health; GESTATIONAL DIABETES-MELLITUS; D DEFICIENCY; D-RECEPTOR; D SUPPLEMENTATION; DNA METHYLATION; GENE-EXPRESSION; WOMEN; RISK; FETAL; ETIOLOGY;

D O I：

10.3390/nu14081649

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Polycystic ovary syndrome (PCOS) is one of the most common endocrine reproductive disorders in women. Vitamin D deficiency is also quite common in this condition. The degree of vitamin D deficiency correlates with the severity of PCOS. Both male and female vitamin D levels play a role in fertility and affect the outcomes of in vitro fertilization (IVF). Moreover, fertility and IVF indicators are improved by vitamin D not only in healthy women but in those diagnosed with PCOS. Both vitamin D deficiency and PCOS increase pregnancy-related complications. Vitamin D supplementation and optimal vitamin D levels decrease both maternal and fetal risk for complications and adverse events. Furthermore, vitamin D supplementation may ameliorate or even prevent pregnancy-related reversible bone loss in mothers. This review emphasizes the roles of vitamin D deficiency and vitamin D supplementation and their correlation with PCOS regarding reproductive health.

引用

页数：17

共 107 条

[1]

Aghadavod E, 2017, INT J FERTIL STERIL, V11, P105, DOI 10.22074/ijfs.2017.4704

[2]

Akhavizadegan H, 2017, UROLOG J, V84, P218, DOI 10.5301/uj.5000248

[3] Vitamin D insufficiency is associated with increased risk of first-trimester miscarriage in the Odense Child Cohort [J].