Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

被引：1159

作者：

Liu, Ruixin ^{[1
]}

Hong, Jie ^{[1
]}

Xu, Xiaoqiang ^{[2
,3
]}

Feng, Qiang ^{[2
,4
]}

Zhang, Dongya ^{[2
]}

Gu, Yanyun ^{[1
]}

Shi, Juan ^{[1
]}

Zhao, Shaoqian ^{[1
]}

Liu, Wen ^{[1
]}

Wang, Xiaokai ^{[2
,3
]}

Xia, Huihua ^{[2
,5
]}

Liu, Zhipeng ^{[2
]}

Cui, Bin ^{[1
,6
,7
]}

Liang, Peiwen ^{[1
]}

Xi, Liuqing ^{[1
]}

Jin, Jiabin ^{[8
]}

Ying, Xiayang ^{[8
]}

Wang, Xiaolin ^{[9
]}

Zhao, Xinjie ^{[9
]}

Li, Wanyu ^{[1
]}

Jia, Huijue ^{[2
,5
,10
]}

Lan, Zhou ^{[2
]}

Li, Fengyu ^{[2
]}

Wang, Rui ^{[1
]}

Sun, Yingkai ^{[1
]}

Yang, Minglan ^{[1
]}

Shen, Yuxin ^{[1
]}

Jie, Zhuye ^{[2
,5
]}

Li, Junhua ^{[2
,5
,10
]}

Chen, Xiaomin ^{[2
]}

Zhong, Huanzi ^{[2
,5
]}

Xie, Hailiang ^{[2
]}

Zhang, Yifei ^{[1
]}

Gu, Weiqiong ^{[1
]}

Deng, Xiaxing ^{[8
]}

Shen, Baiyong ^{[8
]}

Xu, Xun ^{[2
,5
]}

Yang, Huanming ^{[2
,11
]}

Xu, Guowang ^{[9
]}

Bi, Yufang ^{[1
]}

Lai, Shenghan ^{[12
]}

Wang, Jian ^{[2
,11
]}

Qi, Lu ^{[13
,14
]}

Madsen, Lise ^{[2
,15
,16
]}

Wang, Jiqiu ^{[1
]}

Ning, Guang ^{[1
,6
,7
]}

Kristiansen, Karsten ^{[2
,5
,16
]}

Wang, Weiqing ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Natl Clin Res Ctr Endocrine & Metab Dis, State Key Lab Med Genomes,Ruijin Hosp, Shanghai, Peoples R China

[2] BGI Shenzhen, Shenzhen, Peoples R China

[3] Univ Chinese Acad Sci, BGI Educ Ctr, Shenzhen, Peoples R China

[4] BGI Shenzhen, Shenzhen Engn Lab Detect & Intervent Human Intest, Shenzhen, Peoples R China

[5] BGI Shenzhen, China Natl GeneBank, Shenzhen, Peoples R China

[6] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Endocrinol & Metab, Shanghai, Peoples R China

[7] Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China

[8] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Pancreat Dis Ctr,Dept Gen Surg, Shanghai, Peoples R China

[9] Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China

[10] BGI Shenzhen, Shenzhen Key Lab Human Commensal Microorganisms &, Shenzhen, Peoples R China

[11] James D Watson Inst Genome Sci, Hangzhou, Zhejiang, Peoples R China

[12] Johns Hopkins Sch Med, Dept Radiol & Radiol Sci, Baltimore, MD USA

[13] Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA

[14] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA

[15] Natl Inst Nutr & Seafood Res, Bergen, Norway

[16] Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, Copenhagen, Denmark

来源：

NATURE MEDICINE | 2017年 / 23卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Y GASTRIC BYPASS; MONOSODIUM GLUTAMATE; BARIATRIC SURGERY; DIET; THETAIOTAOMICRON; GLUCOSE; IMPACT; ASSOCIATIONS; MODULATION; METAGENOME;

D O I：

10.1038/nm.4358

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.

引用

页码：859 / +

页数：14

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