Posttranscriptional Regulation of Gene Expression by Piwi Proteins and piRNAs

被引：140
作者：
Watanabe, Toshiaki [1 ,2 ]
Lin, Haifan [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, Yale Stem Cell Ctr, New Haven, CT 06519 USA
[2] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06519 USA
来源：
MOLECULAR CELL | 2014年 / 56卷 / 01期
关键词：
INTERACTING RNAS PIRNAS; TUDOR-DOMAIN PROTEIN; DROSOPHILA-MELANOGASTER; CHROMATOID BODIES; ENDOGENOUS SIRNAS; GERMLINE PIRNAS; BODY COMPONENTS; NUAGE FORMATION; ELEGANS PIRNAS; MOUSE GERMLINE;
D O I：
10.1016/j.molcel.2014.09.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Piwi proteins and Piwi-interacting RNAs (piRNAs) are essential for gametogenesis, embryogenesis, and stem cell maintenance in animals. Piwi proteins act on transposon RNAs by cleaving the RNAs and by interacting with factors involved in RNA regulation. Additionally, piRNAs generated from transposons and psuedogenes can be used by Piwi proteins to regulate mRNAs at the posttranscriptional level. Here we discuss piRNA biogenesis, recent findings on posttranscriptional regulation of mRNAs by the piRNA pathway, and the potential importance of this posttranscriptional regulation for a variety of biological processes such as gametogenesis, developmental transitions, and sex determination.
引用
收藏
页码：18 / 27
页数：10
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