Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life

被引：18

作者：

Ardais, Ana Paula ^{[1
]}

Rocha, Andreia S. ^{[1
]}

Borges, Mauricio Felisberto ^{[1
]}

Fioreze, Gabriela T. ^{[1
]}

Sallaberry, Cassia ^{[1
]}

Mioranzza, Sabrina ^{[1
]}

Nunes, Fernanda ^{[1
]}

Pagnussat, Natalia ^{[1
]}

Botton, Paulo Henrique S. ^{[1
]}

Cunha, Rodrigo A. ^{[2
,3
]}

Porciuncula, Lisiane de Oliveira ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Lab Estudos Sistema Purinerg, Inst Ciencias Basicas Saude, Dept Bioquim, BR-90035003 Porto Alegre, RS, Brazil

[2] Univ Coimbra, Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal

[3] Univ Coimbra, Fac Med, P-3004504 Coimbra, Portugal

来源：

BEHAVIOURAL BRAIN RESEARCH | 2016年 / 303卷

关键词：

Brain development; Memory; BDNF; Psychostimulant; Sex differences; Caffeine; ADENOSINE A(2A) RECEPTORS; OPEN-FIELD BEHAVIOR; RECOGNITION MEMORY; DIFFERENTIAL REGULATION; NEUROTROPHIC FACTOR; ANXIETY; BDNF; EXPRESSION; DEFICITS; MODEL;

D O I：

10.1016/j.bbr.2016.01.026

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Caffeine is the psychostimulant most consumed worldwide. In moderate doses, it affords a beneficial effect in adults and upon aging, but has a deleterious effect during brain development. We now tested if caffeine consumption by rats (0.1, 0.3, 1.0 g/L in the drinking water, only during active cycle and weekdays) during adulthood could revert the potentially negative effects of caffeine during early life. Thus, we compared caffeine intake starting 15 days before mating and lasting either up to weaning (development) or up to adulthood, on behavior and synaptic proteins in male and female rats. Recognition memory was impaired only in female rats receiving caffeine (0.3 and 1.0 g/L) during development, coincident with increased proBDNF and unchanged BDNF levels in the hippocampus. Caffeine in both treatment regimens caused hyperlocomotion only in male rats, whereas anxiety-related behavior was attenuated in both sexes by caffeine (1.0 g/L) throughout life. Both caffeine treatment regimens decreased GFAP (as an astrocyte marker) and SNAP-25 (as a nerve terminals marker) in the hippocampus from male rats. TrkB receptor was decreased in the hippocampus from both sexes and treatment regimens. These findings revealed that caffeine intake during a specific time window of brain development promotes sex-dependent behavioral outcomes related to modification in BDNF signaling. Furthermore, caffeine throughout life can overcome the deleterious effects of caffeine on recognition memory during brain development in female rats. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：76 / 84

页数：9

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