Transition Metal- and Oxidant-Free Regioselective Synthesis of 3,4,5-Trisubstituted Pyrazoles by Means of [3+2] Cycloaddition Reactions

被引：8

作者：

Allaka, Bhargava Sai ^{[1
]}

Basavoju, Srinivas ^{[1
]}

Gamidi, Rama Krishna ^{[2
]}

机构：

[1] Natl Inst Technol Warangal Hanamkonda, Dept Chem, Hanamkonda 506004, Telangana, India

[2] CSIR, Natl Chem Lab, Organ Chem Div, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India

来源：

CHEMISTRYSELECT | 2022年 / 7卷 / 11期

关键词：

Cycloaddition; Multicomponent reaction; Oxidant free; Regioselectivity; Transition metal free; 3; 4; 5-trisubstituted pyrazoles; HINDERED CLAISEN CONDENSATION; ONE-POT SYNTHESIS; N-TOSYLHYDRAZONES; DERIVATIVES; ANTIMYCOBACTERIAL; DIAZOACETATES; COMPLEXES; ANALOGS; DESIGN;

D O I：

10.1002/slct.202200605

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient regioselective synthesis of 3,4,5-trisubstituted pyrazoles via transition metal- and oxidant-free, three component [3+2] cycloaddition with thiazolidinedione chalcones, benzaldehydes and N-tosylhydrazine is described. The reaction proceeds through C-C and C-N bond formations under mild reaction conditions to produce structurally diverse polysubstituted pyrazoles in moderate to good yields.

引用

页数：5

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