Therapeutic drug monitoring of immunosuppressive drugs:: focus on mycophenolate mofetil and sirolimus measurement and on sampling of cyclosporine at C2

被引：0

作者：

Royer, B ^{[1
]}

Davani, S ^{[1
]}

Bérard, M ^{[1
]}

Kantelip, JP ^{[1
]}

Muret, P ^{[1
]}

机构：

[1] Hop Jean Minjoz, Lab Pharmacol Clin, F-25030 Besancon, France

来源：

ANNALES DE BIOLOGIE CLINIQUE | 2003年 / 61卷 / 03期

关键词：

immunosuppressive drug; therapeutic drug monitoring; cyclosporin; mycophenolate mofetil; sirolimus;

D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The evolutions in treatments and clinical practices in organ transplantations led to modifications in the therapeutic drug monitoring (TDM) of immunosuppressive drugs. A focus is made regarding the C-2 sampling of cyclosporin, as well as the TDM of mycophenolate mofetil and sirolimus. A review of literature about the evolution of drug monitoring, technical methods and sampling strategies is described. Arguments in favour of TDM are thus a decrease in the frequency of both graft rejection and adverse drug reactions, however, new strategies or new targets are needed in new associations or indications.

引用

页码：251 / 258

页数：8

共 34 条

[11] An immunoassay for the measurement of sirolimus [J].

Jones, K ;

Saadat-Lajevardi, S ;

Lee, T ;

Horwatt, R ;

Hicks, D ;

Johnston, A ;

Holt, DW .

CLINICAL THERAPEUTICS, 2000, 22 :B49-B61

[12]

KAHAN BD, 1990, CLIN CHEM, V36, P1510

[13]

Kahan BD, 2000, J AM SOC NEPHROL, V11, P1122, DOI 10.1681/ASN.V1161122

[14]

Keown P, 2001, TRANSPLANTATION, V72, P1024

[15] Simultaneous estimation of cyclosporin and mycophenolic acid areas under the curve in stable renal transplant patients using a limited sampling strategy [J].

Le Guellec, C ;

Büchler, M ;

Giraudeau, B ;

Le Meur, Y ;

Gakoué, JE ;

Lebranchu, Y ;

Marquet, P ;

Paintaud, G .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2002, 57 (11) :805-811

[16] Relationship of pharmacokinetics to clinical outcomes [J].

Levy, GA .

TRANSPLANTATION PROCEEDINGS, 1999, 31 (03) :1654-1658

[17] Clinical pharmacokinetics and therapeutic drug monitoring of sirolimus [J].

MacDonald, A ;

Scarola, J ;

Burke, JT ;

Zimmerman, JJ .

CLINICAL THERAPEUTICS, 2000, 22 :B101-B121

[18] A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts [J].

MacDonald, AS .

TRANSPLANTATION, 2001, 71 (02) :271-280

[19] Neoral monitoring by simplified sparse sampling area under the concentration-time curve - Its relationship to acute rejection and cyclosporine nephrotoxicity early after kidney transplantation [J].

Mahalati, K ;

Belitsky, P ;

Sketris, I ;

West, K ;

Panek, R .

TRANSPLANTATION, 1999, 68 (01) :55-62

[20]

Mahalati K, 2001, J AM SOC NEPHROL, V12, P828, DOI 10.1681/ASN.V124828

← 1 2 3 4 →