Biodegradable Core-Shell Copolymer-Phospholipid Nanoparticles for Combination Chemotherapy: An In Vitro Study

被引：16

作者：

Ma, Weicheng ^{[1
]}

Xu, Airen ^{[1
]}

Ying, Jingyan ^{[1
]}

Li, Bo ^{[2
]}

Jin, Yi ^{[2
]}

机构：

[1] Ningbo Urinary & Renal Dis Hosp, Clin Pharmacol Res Ctr, Ningbo 315000, Zhejiang, Peoples R China

[2] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2015年 / 11卷 / 07期

关键词：

Core-Shell-Type; Hybrid Particles; Combination Chemotherapy; Biodegradable; Doxorubicin; LIPID/POLYMER PARTICLE ASSEMBLIES; SOLID LIPID NANOPARTICLES; LUNG-CANCER; DRUG-DELIVERY; MULTIDRUG-RESISTANCE; BILAYER-MEMBRANES; CELLS; DIHYDROARTEMISININ; PACLITAXEL; LEUKEMIA;

D O I：

10.1166/jbn.2015.2059

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In the present study, we developed novel core shell-type lipid/particle assemblies comprising poly(lactic-co-glycolic acid) nanoparticle cores coated with a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine shell. Hydrophobic dihydroartemisinin and hydrophilic doxorubicin were co-loaded in the core shell-type lipid/particle assemblies for combination chemotherapy. The physicochemical properties of the dual drug-loaded core shell-type lipid/particle assemblies were characterized. The results of colorimetric cell viability assay and cellular uptake experiments demonstrated that the lipid/particle hybrid could increase the accumulation of doxorubicin accumulation in cell nuclei, thus enhancing cell cytotoxicity. This effect contributed to the high treatment efficiency of dihydroartemisinin and doxorubicin. These biodegradable lipid/polymer hybrid particles could be promising delivery systems to improve combination chemotherapy.

引用

页码：1193 / 1200

页数：8

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