Pregnancy-Related Diseases and Delivery Mode can Affect the Content of Human Milk Oligosaccharides: A Preliminary Study

被引:22
作者
Wang, Xiaoqin [1 ]
Liu, Jing [1 ]
Li, Cheng [1 ]
Xu, Yifan [1 ]
Wang, Xinyi [1 ]
Lu, Yu [1 ]
Zhang, Ting [2 ]
Cao, Hongzhi [3 ]
Huang, Linjuan [1 ]
Wang, Zhongfu [1 ]
机构
[1] Northwest Univ, Coll Food Sci & Technol, Shaanxi Nat Carbohydrate Resource Engn Res Ctr, Xian 710069, Peoples R China
[2] Shaanxi Univ Tradit Chinese Med, Affiliated Hosp 2, Xianyang 712046, Peoples R China
[3] Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250100, Peoples R China
基金
中国国家自然科学基金;
关键词
human milk oligosaccharides; LC-MS; secretor; gestational diabetes mellitus; delivery mode; GESTATIONAL DIABETES-MELLITUS; AMERICAN THYROID ASSOCIATION; ABSOLUTE QUANTITATION; INDUCED HYPERTENSION; BREAST-MILK; WOMEN; GUIDELINES; MANAGEMENT; DIAGNOSIS; SECRETOR;
D O I
10.1021/acs.jafc.2c00147
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Human milk oligosaccharides (HMOs) are the second most abundant carbohydrates in colostrum. In this study, we performed a quantitative analysis of 13 oligosaccharides in 99 colostrum samples obtained from mothers living in Northwest China. The analysis combined liquid chromatography-mass spectrometry (LC-MS) with 2-amino-N-(2-aminoethyl)benzamide (AEAB) labeling and nonsecretors accounted for 17%. Compared with healthy secretor mothers, those with gestational diabetes mellitus presented lower levels of sialylated oligosaccharides, especially 3'-sialyllactose. Colostrum from mothers with pregnancy-induced hypertension had higher levels of fucosylated oligosaccharides, but the difference was not significant, and hypothyroidism appeared to have no effect on HMOs. Most HMOs (especially 6'-sialyllactose) were more abundant in colostrum from mothers who underwent vaginal delivery than a C-section. These findings show that the concentration of total or individual HMOs is affected by multiple factors. These findings provide a reference for evaluating variations in HMO expression among different populations and potential guidance for providing personalized clinical nutrition.
引用
收藏
页码:5207 / 5217
页数:11
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