Synthesis of new pyrimidine-containing compounds: 5-(2-(alkylamino)-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-6-hydroxypyrimidine-2,4(1H,3H)-dione derivatives

被引：3

作者：

Kochia, Khudaidad ^{[1
]}

Bayat, Mohammad ^{[1
]}

Nasri, Shima ^{[1
]}

Mohammadi, Aref ^{[1
]}

机构：

[1] Imam Khomeini Int Univ, Fac Sci, Dept Chem, Qazvin, Iran

来源：

MOLECULAR DIVERSITY | 2020年 / 24卷 / 04期

关键词：

Pyrimidine; Barbituric acid; Ninhydrin; Nitroketene dithioacetals; Indene; PHARMACOKINETICS; DESIGN; ANTIOXIDANT; NINHYDRIN;

D O I：

10.1007/s11030-019-10009-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, the one-pot reaction between primary amines, 1,1-bis-(methylthio)-2-nitroethene, ninhydrin, and barbituric acid as an enolizable C-H-activated compound provides a simple method for the preparation of 5-(2-(alkylamino)-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-6-hydroxypyrimidine-2,4(1H,3H)-dione derivatives with potential synthetic and pharmacological interest. This reaction shows attractive characteristics, such as substrate availability, good yields, existence of numerous hydrogen-bonding possibilities in product, and its mild conditions in ethanol media. Graphic abstract

引用

页码：1015 / 1024

页数：10

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