The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia

被引：49

作者：

Masuzaki, Tomohiro ^{[1
]}

Ayukawa, Yasunori ^{[1
]}

Moriyama, Yasuko ^{[1
]}

Jinno, Yohei ^{[1
]}

Atsuta, Ikiru ^{[1
]}

Ogino, Yoichiro ^{[1
]}

Koyano, Kiyoshi ^{[1
]}

机构：

[1] Kyushu Univ, Fac Dent Sci, Div Oral Rehabil, Sect Removable Prosthodont,Higashi Ku, Fukuoka 8128582, Japan

来源：

BIOMATERIALS | 2010年 / 31卷 / 12期

基金：

日本学术振兴会;

关键词：

Poly (lactic-co-glycolic acid); Microsphere; Fluvastatin; Drug delivery system; Bone formation; Dental implant; BONE MORPHOGENETIC PROTEIN-2; SURGICAL TECHNIQUES; LEUPROLIDE ACETATE; LOCAL APPLICATION; SIMVASTATIN; LOVASTATIN; MICROCAPSULES; OSTEOCLASTS; STABILITY; INCREASES;

D O I：

10.1016/j.biomaterials.2010.01.016

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The aim of this study was to evaluate the effects of newly developed injectable poly (lactic-co-glycolic acid) (PLGA) microspheres containing fluvastatin on osteogenesis around titanium implants in the rat tibia. After confirmation of the sustained-release profile of fluvastatin from the microspheres by an in vitro assay, the microspheres were administered to the back skin of the rats by a single transdermal injection. At 2 and 4 weeks after the implant surgery, the fluvastatin groups showed enhanced new bone formation around the titanium implants without any influence on the serum biochemistry. In addition, the fluvastatin groups showed increased three-point bending strengths of their femurs. The results of this study indicate that a single remote injection of PLGA/fluvastatin microspheres safely and successfully stimulated bone formation around titanium implants and increased the mechanical properties of bone. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3327 / 3334

页数：8

共 33 条

[1] A 15-YEAR STUDY OF OSSEOINTEGRATED IMPLANTS IN THE TREATMENT OF THE EDENTULOUS JAW [J].