Impact of risperidone on leptin and insulin in children and adolescents with autistic spectrum disorders

被引：34

作者：

Srisawasdi, Pornpen ^{[1
]}

Vanwong, Natchaya ^{[2
]}

Hongkaew, Yaowaluck ^{[2
]}

Puangpetch, Apichaya ^{[2
]}

Vanavanan, Somlak ^{[1
]}

Intachak, Boontarika ^{[1
]}

Ngamsamut, Nattawat ^{[3
]}

Limsila, Penkhae ^{[3
]}

Sukasem, Chonlaphat ^{[2
]}

Kroll, Martin H. ^{[4
]}

机构：

[1] Mahidol Univ, Ramathibodi Hosp, Div Clin Chem, Dept Pathol,Fac Med, Rama IV Rd, Bangkok 10400, Thailand

[2] Fac Med, Dept Pathol, Div Pharmacogen & Personalized Med, Bangkok 10400, Thailand

[3] Yuwaprasart Waithayopathum Child & Adolescent Psy, Dept Mental Hlth Serv, Minist Publ Hlth, Samut Prakan 10270, Thailand

[4] Quest Diagnost, 3 Giralda Farms, Madison, NJ 07940 USA

来源：

CLINICAL BIOCHEMISTRY | 2017年 / 50卷 / 12期

关键词：

Autistic spectrum disorders; Risperidone; Metabolic risk factors; Diabetes; Children; Adolescent; ENERGY HOMEOSTASIS; METABOLIC SYNDROME; GLUCOSE; RESISTANCE; ANTIPSYCHOTICS; OBESITY; WEIGHT; ONSET; BOYS; AGE;

D O I：

10.1016/j.clinbiochem.2017.02.003

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: To evaluate the influence of dose and duration of risperidone treatment on cardiovascular and diabetes risk biomarkers in children and adolescents with autistic spectrum disorders (ASDs). Design and methods: In this cross-sectional analysis, a total of 168 ASDs patients (89% male) treated with a risperidone-based regimen for >= 12 months were included. Blood samples were analyzed for glucose and lipid metabolic markers, adiponectin, leptin, prolactin, cortisol and high sensitive C-reactive protein. Results: The mean concentrations of glucose, insulin, prolactin and leptin and HOMA-IR significantly rose with risperidone dosage (all P < 0.025), but those of adiponectin and cortisol did not. Using regression analysis, insulin, leptin, prolactin and glucose concentrations and HOMA-IR show significant association with dosage. None of the markers except adiponectin showed dependence on duration of treatment. However, insulin and leptin concentrations and HOMA-IR clearly increased with increasing both dosage and duration. Dosage and duration of treatment had minimal effect on standard lipid profile and lipoprotein subclasses. Conclusions: Risperidone treatment disturbed glucose homeostasis and endocrine regulation (particularly leptin) in children and adolescents with ASDs, in a dose- and duration-dependent manner, being suggestive of leptin and insulin resistance mechanisms. Metabolic adverse effects, especially development of type 2 diabetes mellitus should be closely monitored, particularly in individuals receiving high doses and/or long-term risperidone treatment. (C) 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：678 / 685

页数：8

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