Deubiquitinases and cancer: A snapshot

被引：33

作者：

Singh, Nishant ^{[1
]}

Singh, Anuradha Bharara ^{[2
]}

机构：

[1] Cleveland State Univ, Dept Biol Sci, Cleveland, OH 44115 USA

[2] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2016年 / 103卷

关键词：

Deubiquitinases; Ubiquitination; Cancer; Deubiquitination; DUBs; DUBs inhibitors; FANCONI-ANEMIA PATHWAY; NF-KAPPA-B; STERICALLY STABILIZED LIPOSOMES; CARCINOMA KB CELLS; PROTEASOME INHIBITOR; UBIQUITIN; PROTEINS; DEGRADATION; ACTIVATION; INITIATION;

D O I：

10.1016/j.critrevonc.2016.04.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ubiquitination is the vital system for controlling protein degradation and regulation of basic cellular processes. Deubiquitinases (DUBs) are emerging as an important regulator of several pathways related to cancer and other diseases. Their ability to detach ubiquitin from the target substrate and regulation of signaling makes it potential target to treat cancer and other fatal diseases. In the current review, we are trying to summarize deubiquitination, and their role in cancer and potential small molecules DUBs inhibitors which can be used as drugs for cancer treatment. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：22 / 26

页数：5

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