Cytotoxic haterumadienone congeners from the Okinawan marine sponge Dysidea sp.

被引：8
作者：
Ueda, Katsuhiro
Ogi, Takayuki
Sato, Atsushi
Siwu, Eric R. O.
Kita, Masaki
Uemura, Daisuke
机构：
[1] Univ Ryukyus, Dept Chem Biol & Marine Sci, Okinawa 9030213, Japan
[2] Nagoya Univ, Dept Chem, Grad Sch Sci, Nagoya, Aichi 4648602, Japan
[3] Nagoya Univ, Res Ctr Mat Sci, Nagoya, Aichi 4648602, Japan
[4] Nagoya Univ, Inst Adv Res, Nagoya, Aichi 468602, Japan
来源：
HETEROCYCLES | 2007年 / 72卷
关键词：
puupehenone congener; sea urchin egg assay; structure-activity relationship; absolute stereochemistry; marine sponge;
D O I：
10.3987/COM-06-S(K)17
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
20-Hydroxyhaterumadienone (1) and haterumadienelactol (2), new haterumadienone (3) congeners, were isolated from the sponge Dysidea sp. together with puupehenone (6) and three known metabolites (7-9) related to 6. The absolute stereochemistry of 1 and the relative stereochemistry of 2 were determined by spectroscopic and chemical analyses. The metabolites (1 and 2) inhibited the division of fertilized sea urchin eggs.
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收藏
页码：655 / 663
页数：9
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