Modular evolution of the purine biosynthetic pathway

被引：82
作者：
Kappock, TJ
Ealick, SE
Stubbe, J
机构：
[1] MIT, Dept Biol, Cambridge, MA 02139 USA
[2] Cornell Univ, Dept Chem & Biol Chem, Olin Lab 380 ST, Ithaca, NY 14853 USA
[3] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 05期
关键词：
D O I：
10.1016/S1367-5931(00)00133-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Structural studies, sequence alignments, and biochemistry have provided new insights into the evolution of the purine biosynthetic pathway. The importance of chemistry, the binding of ribose 5-phosphate (common to all purine biosynthetic intermediates), and transient protein-protein interactions in channeling of chemically unstable intermediates have all been examined in the past few years.
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收藏
页码：567 / 572
页数：6
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