Modular evolution of the purine biosynthetic pathway

被引：81

作者：

Kappock, TJ

Ealick, SE

Stubbe, J

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] Cornell Univ, Dept Chem & Biol Chem, Olin Lab 380 ST, Ithaca, NY 14853 USA

[3] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 05期

关键词：

D O I：

10.1016/S1367-5931(00)00133-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural studies, sequence alignments, and biochemistry have provided new insights into the evolution of the purine biosynthetic pathway. The importance of chemistry, the binding of ribose 5-phosphate (common to all purine biosynthetic intermediates), and transient protein-protein interactions in channeling of chemically unstable intermediates have all been examined in the past few years.

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页码：567 / 572

页数：6

相关论文

共 27 条

[1] STRUCTURES OF APO AND COMPLEXED ESCHERICHIA-COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE [J].

ALMASSY, RJ ;

JANSON, CA ;

KAN, CC ;

HOSTOMSKA, Z .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (13) :6114-6118

[2] Interdomain signaling in glutamine phosphoribosylpyrophosphate amidotransferase [J].

Bera, AK ;

Chen, SH ;

Smith, JL ;

Zalkin, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (51) :36498-36504

[3] REACTIONS CATALYZED BY 5-AMINOIMIDAZOLE RIBONUCLEOTIDE CARBOXYLASES FROM ESCHERICHIA-COLI AND GALLUS-GALLUS - A CASE FOR DIVERGENT CATALYTIC MECHANISMS [J].

FIRESTINE, SM ;

POON, SW ;

MUELLER, EJ ;

STUBBE, J ;

DAVISSON, VJ .

BIOCHEMISTRY, 1994, 33 (39) :11927-11934

[4]

Galperin MY, 1997, PROTEIN SCI, V6, P2639

[5] Phosphatidylinositol phosphate kinase: A link between protein kinase and glutathione synthase folds [J].

Grishin, NV .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 291 (02) :239-247

[6]

HARTMAN SC, 1959, J BIOL CHEM, V234, P1812

[7] An engineered blockage within the ammonia tunnel of carbamoyl phosphate synthetase prevents the use of glutamine as a substrate but not ammonia [J].

Huang, XY ;

Raushel, FM .

BIOCHEMISTRY, 2000, 39 (12) :3240-3247

[8] Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site [J].

Krahn, JM ;

Kim, JH ;

Burns, MR ;

Parry, RJ ;

Zalkin, H ;

Smith, JL .

BIOCHEMISTRY, 1997, 36 (37) :11061-11068

[9] MOLSCRIPT - A PROGRAM TO PRODUCE BOTH DETAILED AND SCHEMATIC PLOTS OF PROTEIN STRUCTURES [J].

KRAULIS, PJ .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1991, 24 :946-950

[10] The structure of SAICAR synthase:: an enzyme in the de novo pathway of purine nucleotide biosynthesis [J].

Levdikov, VM ;

Barynin, VV ;

Grebenko, AI ;

Melik-Adamyan, WR ;

Lamzin, VS ;

Wilson, KS .

STRUCTURE, 1998, 6 (03) :363-376