Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study

被引：6

作者：

Kotiloglu-Karaa, Esin ^{[1
]}

Kele, Beatrix ^{[2
]}

Kulasegaran-Shylini, Raghavendran ^{[2
]}

Broad, Claire E. ^{[2
]}

Owoyemi, Dola ^{[2
]}

Martin, Joanne ^{[4
]}

MacPhail, Graham ^{[1
]}

Iliodromiti, Stamatina ^{[3
]}

Riddell, Anna ^{[2
]}

Alexander, Eliza ^{[2
]}

Cutino-Moguel, Teresa ^{[2
,4
]}

机构：

[1] Royal London Hosp, Dept Cellular Pathol, Barts Hlth, London, England

[2] Royal London Hosp, Div Infect, Barts Hlth, London, England

[3] Queen Mary Univ London, Ctr Womens Hlth, Inst Populat Hlth Sci, London, England

[4] Queen Mary Univ, Ctr Genom & Child Hlth, Blizard Inst, London, England

来源：

CLINICAL INFECTIOUS DISEASES | 2022年 / 75卷 / 01期

关键词：

placenta; SARS; CoV; 2; fibrin deposition;

D O I：

10.1093/cid/ciac173

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We observed an increased frequency of massive perivillous fibrin deposition (MPFD) during the second coronavirus disease 2019 (COVID-19) pandemic wave dominated by the Alpha variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MPFD associated with 100% reverse transcription polymerase chain reaction (RT-PCR) positivity for SARS-CoV-2 and detection by immunohistochemistry. The Alpha variant was identified in all placentas with MPFD that could be sequenced.

引用

页码：E1176 / E1179

页数：4

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