Epigenetics in Drug Response

被引：13

作者：

Cascorbi, I. ^{[1
]}

Schwab, M. ^{[2
,3
]}

机构：

[1] Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, Campus Kiel, Kiel, Germany

[2] Dr Margarete Fischer Bosch Inst Clin Pharmacol, Auerbachstr 112, Stuttgart, Germany

[3] Univ Tubingen Hosp, Dept Clin Pharmacol, Tubingen, Germany

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2016年 / 99卷 / 05期

关键词：

PHARMACOGENOMICS;

D O I：

10.1002/cpt.349

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hereditary genetic variation has been identified to contribute significantly to drug response. More recently, there is increasing evidence that individual phenotypic differences may also result from epigenetic alterations such as histone-acetylation or DNA-methylation. Moreover, interactions with noncoding RNAs contribute to protein expression and may modulate drug action. Currently, intriguing developments of novel therapeutic approaches through epigenetic drugs are emerging. The overall complexity of epigenetics in drug action, however, is so far only little understood.

引用

页码：468 / 470

页数：3

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