Human African trypanosomiasis:: diagnosis, relapse and survival after severe melarsoprol-induced encephalopathy

被引：17
作者：
Checkley, A. M.
Pepin, J.
Gibson, W. C.
Taylor, M. N.
Jager, H. R.
Mabey, D. C.
机构：
[1] Hosp Trop Dis, London NW1 0PE, England
[2] Univ Coll Hosp, London, England
[3] Univ Sherbrooke, Dept Microbiol & Infect Dis, Sherbrooke, PQ J1K 2R1, Canada
[4] Univ Sherbrooke, Ctr Int Hlth, Sherbrooke, PQ J1K 2R1, Canada
[5] Univ Bristol, Sch Biol Sci, Bristol, Avon, England
[6] Inst Neurol, London WC1N 3BG, England
[7] London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1, England
来源：
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2007年 / 101卷 / 05期
关键词：
trypanosomiasis; Trypanosoma brucei rhodesiense; melarsoprol; encephalopathy; magnetic resonance imaging;
D O I：
10.1016/j.trstmh.2006.12.001
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
We describe a case of human African trypanosomiasis with a number of unusual features. The clinical presentation was subacute, but the infection was shown to be due to Trypanosoma brucei rhodesiense. The infection relapsed twice following treatment and the patient developed a melarsoprol-associated encephatopathy. Magnetic resonance imaging (MRI) findings were suggestive of microhaemorrhages, well described in autopsy studies of encephalopathy but never before shown on MRI. The patient survived severe encephalopathy with a locked-in syndrome. Our decision to provide ongoing life support may be useful to physicians treating similar cases in a setting where intensive care facilities are available. (c) 2007 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：523 / 526
页数：4
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