Involvement of Sonic hedgehog in the cell growth of LK-2 cells, human lung squamous carcinoma cells

被引：27
作者：
Fujita, E
Khoroku, Y
Urase, K
Tsukahara, T
Momoi, MY
Kumagai, H
Takemura, T
Kuroki, T
Momoi, T
机构：
[1] NATL CTR NEUROL & PSYCHIAT,NATL INST NEUROSCI,DEPT NEUROMUSCULAR RES,KODAIRA,TOKYO 187,JAPAN
[2] JICHI MED SCH,DEPT PEDIAT,MINAMI KAWACHI,TOCHIGI 32904,JAPAN
[3] ASAHI GLASS CO LTD,KANAGAWA KU,YOKOHAMA,KANAGAWA 221,JAPAN
[4] JAPANESE RED CROSS,MED CTR,DEPT PATHOL,SHIBUYA KU,TOKYO 150,JAPAN
[5] SHOUWA UNIV,MOL ONCOL RES CTR,SHINAGAWA KU,TOKYO 142,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 238卷 / 02期
关键词：
D O I：
10.1006/bbrc.1997.7262
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mutation of the Patched gene has been detected in human inherited basal cell nevus syndrome (BCNS) and sporadic basal cell carcinomas (BCC), suggesting a strong relation between a Sonic hedgehog-Patched signal and cell proliferation. In the present study, we demonstrate that Sonic hedgehog is expressed in human lung squamous carcinoma (LK-2 and EBC-1) and some adenocarcinoma cell lines. The expression of Sonic hedgehog is also detected in the human lung squamous carcinoma tissues, but not in the normal lung tissue of the same patient. The N-terminal region of Sonic hedgehog stimulates the incorporation of BrdU into LK-2 cells and stimulates their cell growth, while anti-Shh-N inhibits their cell growth. These results suggest that a Sonic hedgehog signal is involved in the cell growth of LK-2 cells. (C) 1997 Academic Press.
引用
收藏
页码：658 / 664
页数：7
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