Deep eutectic solvent mediated synthesis of quinazolinones and dihydroquinazolinones: synthesis of natural products and drugs

被引：53

作者：

Ghosh, Suman Kr ^{[1
]}

Nagarajan, Rajagopal ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India

来源：

RSC ADVANCES | 2016年 / 6卷 / 33期

关键词：

UREA-SALT MIXTURES; ONE-POT SYNTHESIS; IONIC LIQUIDS; 2,3-DIHYDROQUINAZOLIN-4(1H)-ONE DERIVATIVES; EFFICIENT SYNTHESIS; ORGANIC-SYNTHESIS; AQUEOUS-MEDIA; ALKALOID BOUCHARDATINE; RECYCLABLE CATALYST; SUSTAINABLE MEDIA;

D O I：

10.1039/c6ra00855k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mild and greener protocol was developed to synthesize substituted quinazolinones and dihydroquinazolinones via deep eutectic solvent (DES) mediated cyclization with a series of aliphatic, aromatic, and heteroaromatic aldehydes in good to excellent yields. This greener strategy was further utilised to synthesize various quinazolinone natural products and drugs.

引用

页码：27378 / 27387

页数：10

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