Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin

被引：42

作者：

Xu, Ying ^{[1
,2
]}

Peng, Ruchao ^{[2
]}

Zhang, Wei ^{[2
]}

Qi, Jianxun ^{[2
]}

Song, Hao ^{[3
]}

Liu, Sheng ^{[1
,2
]}

Wang, Haiyuan ^{[2
,4
]}

Wang, Min ^{[2
]}

Xiao, Haixia ^{[5
]}

Fu, Lifeng ^{[2
,6
]}

Fan, Zheng ^{[2
]}

Bi, Yuhai ^{[2
,6
]}

Yan, Jinghua ^{[6
,7
,8
]}

Shi, Yi ^{[2
,6
,7
,8
]}

Gao, George F. ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

机构：

[1] Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China

[2] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

[3] Chinese Acad Sci, Beijing Inst Life Sci, RNIH, Beijing 100101, Peoples R China

[4] Guangxi Univ, Coll Anim Sci & Vet Med, Lab Anim Infect Dis, Nanning 530004, Peoples R China

[5] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Lab Prot Engn & Vaccines, Tianjin 300308, Peoples R China

[6] Chinese Acad Sci CASCIRE, Ctr Influenza Res & Early Warning, Beijing 100101, Peoples R China

[7] Univ Chinese Acad Sci, Savaid Med Sch, Beijing 101408, Peoples R China

[8] Shenzhen Third Peoples Hosp, Shenzhen Key Lab Pathogen & Immun, Shenzhen 518112, Guangdong, Peoples R China

来源：

CELL REPORTS | 2019年 / 29卷 / 08期

基金：

中国国家自然科学基金;

关键词：

A VIRUS; AIRBORNE TRANSMISSION; HUMAN INFECTION; SPECIFICITY; ORIGIN; ANTIGENICITY; H9N2;

D O I：

10.1016/j.celrep.2019.10.047

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since 2013, H7N9 avian influenza viruses (AIVs) have caused more than 1,600 human infections, posing a threat to public health. An emerging concern is whether H7N9 AIVs will cause pandemics among humans. Molecular analysis of hemagglutinin (HA), which is a critical determinant of interspecies transmission, shows that the current H7N9 AIVs are still dual-receptor tropic, indicating limited human-to-human transmission potency. Mutagenesis and structural studies reveal that a G186V substitution is sufficient for H7N9 AIVs to acquire human receptor-binding capacity, and a Q226L substitution would favor binding to both avian and human receptors only when paired with A138/V186/P221 hydrophobic residues. These data suggest a different evolutionary route of H7N9 viruses compared to other AIV-subtype HAs.

引用

页码：2217 / +

页数：17

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