A novel single step solid-phase extraction combined with bromine derivatization method for rapid determination of acrylamide in coffee and its products by stable isotope dilution ultra-performance liquid chromatography tandem triple quadrupole electrospray ionization mass spectrometry

被引：19

作者：

Wang, Junlin ^{[1
]}

Cai, Zengxuan ^{[1
]}

Zhang, Nianhua ^{[1
]}

Hu, Zhengyan ^{[1
]}

Zhang, Jing ^{[1
]}

Ying, Ying ^{[1
]}

Zhao, Yongxin ^{[1
]}

Feng, Liang ^{[1
]}

Zhang, Jingshun ^{[1
]}

Wu, Pinggu ^{[1
]}

机构：

[1] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou 310051, Peoples R China

来源：

FOOD CHEMISTRY | 2022年 / 388卷

基金：

中国国家自然科学基金;

关键词：

Acrylamide; Derivatization; Coffee; UPLC-MS; MS; Solid-phase extraction;

D O I：

10.1016/j.foodchem.2022.132977

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This work aimed to establish a novel determination method for acrylamide in coffee and its products by ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Acrylamide in samples were prepared by a single-step solid-phase extraction clean-up using mixed mode sorbents. The bromine derivatization efficiency of acrylamide and its internal standard were improved at an acidic condition. After derivation, the retention capability of acrylamide and its resistance to interference were significantly improved. The limit of detection (LOD) and the limit of quantification (LOQ) were 1.2 and 4 mu g/kg for roasted and instant coffees, while they were 0.24 and 0.8 mu g/kg for ready-to-drink coffees. The average recoveries for acrylamide ranged from 99.3 to 102.2% in coffee and its products. All the results showed that the developed method was simple, quick, specific and suitable for screening and determination of acrylamide in batch samples of coffee and its products.

引用

页数：7

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