Mineralized Collagen-Based Composite Bone Materials for Cranial Bone Regeneration in Developing Sleep

被引:34
作者
Wang, Shuo [1 ]
Yang, Yongdong [1 ]
Zhao, Zhijun [2 ]
Wang, Xiumei [1 ]
Mikos, Antonios G. [3 ]
Qiu, Zhiye [4 ]
Song, Tianxi [4 ]
Sun, Xiaodan [1 ]
Zhao, Lingyun [1 ]
Zhang, Chunyang [2 ]
Cui, Fuzhai [1 ]
机构
[1] Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China
[2] Baotou Med Sch, Affiliated Hosp 1, Dept Neurosurg, Baotou 014010, Peoples R China
[3] Rice Univ, Dept Bioengn, Houston, TX 77030 USA
[4] Beijing Allgens Med Sci & Technol Co Ltd, Beijing 100176, Peoples R China
来源
ACS BIOMATERIALS SCIENCE & ENGINEERING | 2017年 / 3卷 / 06期
关键词
mineralized collagen; cranial bone; bone regeneration; developing sheep; bone tissue engineering; MACROPOROUS CALCIUM-PHOSPHATE; STEM-CELLS; OSTEOGENIC DIFFERENTIATION; DEFECTS; CRANIOPLASTY; SCAFFOLDS; HEAD; DURA; MATRIX; MODEL;
D O I
10.1021/acsbiomaterials.7b00159
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Cranial bone defects remain a great challenging problem in clinical settings, the influences of which are serious because of the intricate complications and related social problems, especially for young children with rapidly growing skulls. Currently, an increasing number of bone materials are being developed for cranial bone defects repair. In this study, two different biodegradable composite bone materials based on mineralized collagen (MC), with compact/porous structure, were constructed to promote bone regeneration for large cranial bone defect repair of one-month-old baby sheep. The porous MC (pMC) scaffold had interconnected porous structure with a porosity of about 73% and a 20-150 mu m pore size range, and the compact MC (cMC) showed no distinct pore structure. Mechanical tests indicated that the compressive strength and elastic modulus of cMC and pMC were comparable with those of natural compact and cancellous bone, respectively. Both of these two MC scaffolds possessed good biocompatibility and supported osteoblasts adhesion and proliferation in vitro. A one-month-old sheep cranial bone defect model was first established to investigate the cranial bone regeneration behaviors in vivo, which was evaluated by CT imaging, X-rays scans, and histological assessments. It was found that the pMC promoted bone ingrowth from the diploic layer of surrounding cranium and dura mater-derived osteogenesis at three months after surgery, along with gradual biodegradation. In contrast, the cMC had very little biodegradation but could promote bone formation beneath the scaffold through dura mater-derived osteogenesis pathway. Furthermore, Ti-mesh restricted the growth of surrounding cranial bone in the rapidly growing sheep, thereby causing obvious deformation of the skull at six months after surgery, whereas no visible geometric deformation of skull occurred in the cMC and pMC groups. Our findings suggested that the MC-based composite bone materials have great promise for the repair of large cranial bone defects in a developing skull.
引用
收藏
页码:1092 / 1099
页数:8
相关论文
共 33 条
  • [1] Osteogenic differentiation of dura mater stem cells cultured in vitro on three-dimensional porous scaffolds of poly(ε-caprolactone) fabricated via co-extrusion and gas foaming
    Aronin, C. E. Petrie
    Cooper, J. A., Jr.
    Sefcik, L. S.
    Tholpady, S. S.
    Ogle, R. C.
    Botchwey, E. A.
    [J]. ACTA BIOMATERIALIA, 2008, 4 (05) : 1187 - 1197
  • [2] Cranioplasty: Review of materials and techniques
    Aydin, Seckin
    Kucukyuruk, Baris
    Abuzayed, Bashar
    Aydin, Sabri
    Sanus, Galip Zihni
    [J]. JOURNAL OF NEUROSCIENCES IN RURAL PRACTICE, 2011, 2 (02) : 162 - 167
  • [3] Flat bones and sutures formation in the human cranial vault during prenatal development and infancy: A computational model
    Burgos-Florez, F. J.
    Gavilan-Alfonso, M. E.
    Garzon-Alvarado, D. A.
    [J]. JOURNAL OF THEORETICAL BIOLOGY, 2016, 393 : 127 - 144
  • [4] Umbilical cord and bone marrow mesenchymal stem cell seeding on macroporous calcium phosphate for bone regeneration in rat cranial defects
    Chen, Wenchuan
    Liu, Jun
    Manuchehrabadi, Navid
    Weir, Michael D.
    Zhu, Zhimin
    Xu, Hockin H. K.
    [J]. BIOMATERIALS, 2013, 34 (38) : 9917 - 9925
  • [5] The enamel softening and loss during early erosion studied by AFM, SEM and nanoindentation
    Cheng, Zhen-Jiang
    Wang, Xiu-Mei
    Cui, Fu-Zhai
    Ge, Jun
    Yan, Jian-Xin
    [J]. BIOMEDICAL MATERIALS, 2009, 4 (01)
  • [6] Decompressive Craniectomy and Early Cranioplasty for the Management of Severe Head Injury: A Prospective Multicenter Study on 147 Patients
    Chibbaro, Salvatore
    Di Rocco, Fedreico
    Mirone, Giuseppe
    Fricia, Marco
    Makiese, Orphee
    Di Emidio, Paolo
    Romano, Antonio
    Vicaut, Eric
    Menichelli, Alina
    Reiss, Alisha
    Mateo, Joaquim
    Payen, Didier
    Guichard, Jean Pierre
    George, Bernard
    Bresson, Damien
    [J]. WORLD NEUROSURGERY, 2011, 75 (3-4) : 558 - 562
  • [7] Self-assembly of mineralized collagen composites
    Cui, Fu-Zhai
    Li, Yan
    Ge, Jun
    [J]. MATERIALS SCIENCE & ENGINEERING R-REPORTS, 2007, 57 (1-6) : 1 - 27
  • [8] Bone regeneration in a rabbit critical-sized skull defect using autologous adipose-derived cells
    Di Bella, Claudia
    Farlie, Peter
    Penington, Anthony J.
    [J]. TISSUE ENGINEERING PART A, 2008, 14 (04) : 483 - 490
  • [9] Osteogenesis in calvarial defects: Contribution of the dura, the pericranium, and the surrounding bone in adult versus infant animals
    Gosain, AK
    Santoro, TD
    Song, LS
    Capel, CC
    Sudhakar, PV
    Madoub, HS
    [J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 2003, 112 (02) : 515 - 527
  • [10] HOBAR PC, 1993, PLAST RECONSTR SURG, V92, P405