Treadmill exercise alters histone acetylation differently in rats exposed or not exposed to aversive learning context

被引：9

作者：

Ferreira de Meireles, Louisiana Carolina ^{[1
]}

Bertoldi, Karine ^{[2
]}

Elsner, Viviane Rostirola ^{[2
,3
]}

Moyses, Felipe dos Santos ^{[2
,4
]}

Siqueira, Ionara Rodrigues ^{[1
,2
,5
]}

机构：

[1] Univ Fed Rio Grande do Sul, Programa Posgrad Med Ciencias Med, BR-90050170 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Biol Fisiol, BR-90050170 Porto Alegre, RS, Brazil

[3] Ctr Univ Metodista IPA, Programa Posgrad Biociencias & Reabilitacao, Porto Alegre, RS, Brazil

[4] Univ Reg Alto Uruguai Campus Erechim, Dept Ciencias Biol, Porto Alegre, RS, Brazil

[5] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Farmacol, BR-90050170 Porto Alegre, RS, Brazil

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2014年 / 116卷

关键词：

H3S10; phosphorylation; H3K14; acetylation; Exercise; Aversive memory; Hippocampus; Rats; MEMORY;

D O I：

10.1016/j.nlm.2014.10.008

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Epigenetic modifications have been linked to memory formation after learning context exposure and to exercise effects on memory performance. The aim of this study was to investigate the effect of treadmill exercise (20 min/day during 2 weeks) on H3K14 acetylation and H3S10 phosphorylation levels in the hippocampi of 3-month-old Wistar rats exposed and not exposed to aversive learning context. Male Wistar rats aged 2-3 months were assigned to non-exercised (sedentary) and exercised (running daily for 20 min for 2 weeks) groups. Single-trial step-down inhibitory avoidance (IA) conditioning was employed as an aversive memory model. Epigenetic parameters were determined 30 min after the IA test. A decrease in the H3K14 acetylation in the hippocampus 24 h after IA training (30 min after test session) was observed. Exercise reversed the IA effect, and no effect was observed in the non-IA exposed group. Our data support the hypothesis that modulation of H3K14 acetylation levels in the hippocampus might be related, at least in part, to exercise effects on aversive memory. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：193 / 196

页数：4

共 22 条

[21] Experience-Dependent Epigenetic Modifications in the Central Nervous System [J].