Meta-Analysis of the Association between Variants in ABCA7 and Alzheimer's Disease

被引：18

作者：

Ma, Fang Chen ^{[1
]}

Wang, Hui-Fu ^{[2
]}

Cao, Xi-Peng ^{[3
]}

Tan, Chen-Chen ^{[2
]}

Tan, Lan ^{[2
]}

Yu, Jin-Tai ^{[2
,3
]}

机构：

[1] Weifang Med Univ, Qingdao Municipal Hosp, Dept Neurol, Qingdao, Peoples R China

[2] Qingdao Univ, Qingdao Municipal Hosp, Dept Neurol, Qingdao, Peoples R China

[3] Qingdao Univ, Qingdao Municipal Hosp, Clin Res Ctr, Qingdao, Peoples R China

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2018年 / 63卷 / 04期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

ABCA7; Alzheimer's disease; loss-of-function; meta-analysis; GENOME-WIDE ASSOCIATION; OF-FUNCTION VARIANTS; GENETIC-VARIANTS; HAN CHINESE; POPULATION; RISK; MUTATIONS; AMERICANS; LOCI; BIAS;

D O I：

10.3233/JAD-180107

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ATP-binding cassette transporter A7 (ABCA7) was identified as a known risk factor for Alzheimer's disease (AD). However, the relation between ABCA7 and AD was still inconsistent across these studies. Here, our meta-analysis aimed at confirming the association of ABCA7 with AD. Finally, 16 case-control studies (63747 versus 85833) were retrieved from PubMed and other databases. Three common loci were confirmed to increase the risk of AD (rs3764650: OR = 1.20, 95% CI = 1.16-1.24; rs3752246: OR = 1.13,95% CI = 1.08-1.19; rs4147929: OR = 1.17, 95% CI = 1.10-1.24), but the associations varied among the different races. Furthermore, ABCA7 loss-of-function (LOF) mutations conferred a higher risk for AD than did the above variants (LOF: OR = 1.78, 95% = 1.43-2.22). In conclusion, ABCA7 genetic variants, especially the LOF mutations, were significantly associated with the risk of AD.

引用

页码：1261 / 1267

页数：7

共 31 条

[1] ABCA7 loss-of-function variants, expression, and neurologic disease risk [J].

Allen, Mariet ;

Lincoln, Sarah J. ;

Corda, Morgane ;

Watzlawik, Jens O. ;

Carrasquillo, Minerva M. ;

Reddy, Joseph S. ;

Burgess, Jeremy D. ;

Thuy Nguyen ;

Malphrus, Kimberly ;

Petersen, Ronald C. ;

Graff-Radford, Neill R. ;

Dickson, Dennis W. ;

Ertekin-Taner, Nilufer .

NEUROLOGY-GENETICS, 2017, 3 (01)

[2] Associations Between Genetic Variants in 19p13 and 19q13 Regions and Susceptibility to Alzheimer Disease: A Meta-Analysis [J].

Bao, Jie ;

Wang, Xiao-jie ;

Mao, Zong-fu .

MEDICAL SCIENCE MONITOR, 2016, 22 :234-243

[3] OPERATING CHARACTERISTICS OF A BANK CORRELATION TEST FOR PUBLICATION BIAS [J].

BEGG, CB ;

MAZUMDAR, M .

BIOMETRICS, 1994, 50 (04) :1088-1101

[4] The Clinical Effect of Metformin on the Survival of Lung Cancer Patients with Diabetes: A Comprehensive Systematic Review and Meta-analysis of Retrospective Studies [J].

Cao, Xun ;

Wen, Zhe-Sheng ;

Wang, Xu-Dong ;

Li, Yong ;

Liu, Kui-Yuan ;

Wang, Xin .

JOURNAL OF CANCER, 2017, 8 (13) :2532-2541

[5] Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD [J].

Carrasquillo, Minerva M. ;

Khan, Qurat ul Ain ;

Murray, Melissa E. ;

Krishnan, Siddharth ;

Aakre, Jeremiah ;

Pankratz, V. Shane ;

Thuy Nguyen ;

Ma, Li ;

Bisceglio, Gina ;

Petersen, Ronald C. ;

Younkin, Steven G. ;

Dickson, Dennis W. ;

Boeve, Bradley F. ;

Graff-Radford, Neill R. ;

Ertekin-Taner, Niluefer .

NEUROLOGY, 2014, 82 (16) :1455-1462

[6] Association of GWAS Top Hits With Late-onset Alzheimer Disease in Korean Population [J].

Chung, Sun Ju ;

Lee, Jae-Hong ;

Kim, Seong Yoon ;

You, Sooyeoun ;

Kim, Mi Jung ;

Lee, Joo-Yong ;

Koh, Jaeyoung .

ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2013, 27 (03) :250-257

[7] ABCA7 frameshift deletion associated with Alzheimer disease in African Americans [J].

Cukier, Holly N. ;

Kunkle, Brian W. ;

Vardarajan, Badri N. ;

Rolati, Sophie ;

Hamilton-Nelson, Kara L. ;

Kohli, Martin A. ;

Whitehead, Patrice L. ;

Dombroski, Beth A. ;

Van Booven, Derek ;

Lang, Rosalyn ;

Dykxhoorn, Derek M. ;

Farrer, Lindsay A. ;

Cuccaro, Michael L. ;

Vance, Jeffery M. ;

Gilbert, John R. ;

Beecham, Gary W. ;

Martin, Eden R. ;

Carney, Regina M. ;

Mayeux, Richard ;

Schellenberg, Gerard D. ;

Byrd, Goldie S. ;

Haines, Jonathan L. ;

Pericak-Vance, Margaret A. .

NEUROLOGY-GENETICS, 2016, 2 (03)

[8] Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study [J].

Cuyvers, Elise ;

De Roeck, Arne ;

Van den Bossche, Tobi ;

Van Cauwenberghe, Caroline ;

Bettens, Karolien ;

Vermeulen, Steven ;

Mattheijssens, Maria ;

Peeters, Karin ;

Engelborghs, Sebastiaan ;

Vandenbulcke, Mathieu ;

Vandenberghe, Rik ;

De Deyn, Peter P. ;

Van Broeckhoven, Christine ;

Sleegers, Kristel .

LANCET NEUROLOGY, 2015, 14 (08) :814-822

[9] Role of ABCA7 loss-of-function variant in Alzheimer's disease: a replication study in European-Americans [J].

Del-Aguila, Jorge L. ;

Fernandez, Maria Victoria ;

Jimenez, Jessica ;

Black, Kathleen ;

Ma, Shengmei ;

Deming, Yuetiva ;

Carrell, David ;

Saef, Ben ;

Howells, Bill ;

Budde, John ;

Cruchaga, Carlos .

ALZHEIMERS RESEARCH & THERAPY, 2015, 7

[10] Meta-analysis in clinical trials revisited [J].

DerSimonian, Rebecca ;

Laird, Nan .

CONTEMPORARY CLINICAL TRIALS, 2015, 45 :139-145

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