Krapfen/dMyd88 is required for the establishment of dorsoventral pattern in the Drosophila embryo

被引：38

作者：

Charatsi, I ^{[1
]}

Luschnig, S ^{[1
]}

Bartoszewski, S ^{[1
]}

Nüsslein-Volhard, C ^{[1
]}

Moussian, B ^{[1
]}

机构：

[1] Max Planck Inst Entwicklungsbiol, Genet Abt, D-72076 Tubingen, Germany

来源：

MECHANISMS OF DEVELOPMENT | 2003年 / 120卷 / 02期

关键词：

Drosophila; development; dorsoventral axis; pattern formation; axis specification; tube; pelle; MyD88; toll; torso;

D O I：

10.1016/S0925-4773(02)00410-0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In Drosophila, the dorsoventral axis is set up by the action of the dorsal group of genes and cactus, which have been ordered genetically in a linear pathway. We have identified and characterised krapfen (kra) as a new member of the dorsal-group genes. kra encodes for the Drosophila homologue of MyD88, an adapter protein operating in the mammalian IL-1 pathway. Epistasis experiments reveal that kra acts between the receptor Toll and the cytoplasmic factor Tube. We show that there is a direct interaction between Kra and Tube presumably mediated by the death domains present in both proteins. Tube in turn interacts with its downstream effector Pelle through death domain association. We therefore suggest that upon Toll activation, Kra associates with Pelle and Tube, in an heterotrimeric complex. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：219 / 226

页数：8

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