Pro-Oxidant Action of Pyrroloquinoline Quinone: Characterization of Protein Oxidative Modifications

被引：21

作者：

Ishii, Takeshi ^{[1
,2
]}

Akagawa, Mitsugu ^{[3
]}

Naito, Yuji ^{[4
]}

Handa, Osamu ^{[4
]}

Takagi, Tomohisa ^{[4
]}

Mori, Taiki ^{[1
,2
]}

Kumazawa, Shigenori ^{[1
,2
]}

Yoshikawa, Toshikazu ^{[4
]}

Nakayama, Tsutomu ^{[1
,2
]}

机构：

[1] Univ Shizuoka, Dept Food & Nutr Sci, Shizuoka 4228526, Japan

[2] Univ Shizuoka, Global COE Program, Shizuoka 4228526, Japan

[3] Osaka Prefecture Univ, Grad Sch Life & Environm Sci, Div Appl Life Sci, Dept Biol Chem, Sakai, Osaka 5998531, Japan

[4] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Mol Gastroenterol & Hepatol, Kyoto 6028566, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2010年 / 74卷 / 03期

关键词：

pyrroloquinoline quinone; prooxidant action; protein oxidative modification; ANTIOXIDANT; VITAMIN; PQQ;

D O I：

10.1271/bbb.90764

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pyrroloquinoline quinone (PQQ), a putative essential nutrient, is a redox modulator in cell and animal models. Here we characterized PQQ-induced protein oxidative modifications in a model peptide and protein, and we propose that the mechanism of protein modification by PQQ is redox cycling-mediated oxidation. PQQ may contribute to the regulation of intracellular protein functions through its prooxidant action.

引用

页码：663 / 666

页数：4

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