Somatosensory innervation of the oral mucosa of adult and aging mice

被引:59
作者
Moayedi, Yalda [1 ]
Duenas-Bianchi, Lucia F. [2 ]
Lumpkin, Ellen A. [1 ,3 ,4 ]
机构
[1] Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY 10032 USA
[2] Columbia Univ, Dept Physiol & Cellular Biophys, SPURS Biomed Res Program, Med Ctr, New York, NY 10032 USA
[3] Columbia Univ, Dept Dermatol, New York, NY 10032 USA
[4] Columbia Univ, Program Neurobiol & Behav, New York, NY 10032 USA
来源
SCIENTIFIC REPORTS | 2018年 / 8卷
关键词
SENSORY NERVE-ENDINGS; MERKEL-NEURITE COMPLEXES; AGE-RELATED-CHANGES; HARD PALATE; MECHANORECEPTIVE AFFERENTS; STEREOGNOSTIC ABILITY; MEISSNER CORPUSCLES; FUNGIFORM PAPILLAE; LINGUAL NERVE; LIGHT-TOUCH;
D O I
10.1038/s41598-018-28195-2
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Oral mechanoreception is implicated in fundamental functions including speech, food intake and swallowing; yet, the neuroanatomical substrates that encode mechanical stimuli are not well understood. Tactile perception is initiated by intricate mechanosensitive machinery involving dedicated cells and neurons. This signal transduction setup is coupled with the topology and mechanical properties of surrounding epithelium, thereby providing a sensitive and accurate system to detect stress fluctuations from the external environment. We mapped the distribution of anatomically distinct neuronal endings in mouse oral cavity using transgenic reporters, molecular markers and quantitative histomorphometry. We found that the tongue is equipped with an array of putative mechanoreceptors that express the principal mechanosensory channel Piezo2, including end bulbs of Krause innervating individual filiform papillae and a novel class of neuronal fibers innervating the epithelium surrounding taste buds. The hard palate and gums are densely populated with three classes of sensory afferents organized in discrete patterns including Merkel cell-neurite complexes, Meissner's corpuscles and glomerular corpuscles. In aged mice, we find that palatal Merkel cells reduce in number at key timepoints that correlate with impaired oral abilities, such as swallowing and mastication. Collectively, this work identifies the mechanosensory architecture of oral tissues involved in feeding.
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页数:14
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