Individualizing salvage regimens:: the inhibitory quotient (Ctrough/IC50) as predictor of virological response

被引：27

作者：

Casado, JL ^{[1
]}

Moreno, A ^{[1
]}

Sabido, R ^{[1
]}

Martí-Belda, P ^{[1
]}

Antela, A ^{[1
]}

Dronda, F ^{[1
]}

Perez-Elías, MJ ^{[1
]}

Moreno, S ^{[1
]}

机构：

[1] Hosp Ramon & Cajal, Dept Infect Dis, E-28034 Madrid, Spain

来源：

AIDS | 2003年 / 17卷 / 02期

关键词：

D O I：

10.1097/00002030-200301240-00019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Increased drug levels could overcome resistance and improve the response to a salvage regimen. We evaluate the inhibitory quotient (IQ, C-trough/protein-binding corrected IC50) as a predictor of virological response in 52 patients included in two dual protease inhibitor (PI)-based salvage regimens. The HIV-RNA level decrease at 12 weeks was greater in patients who achieved an IQ greater than 1. The IQ could be useful to improve the virological response to a dual PI salvage regimen.

引用

页码：262 / 264

页数：3

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